Display options
Cite
Schaff Z, Lotz G, Schulte-Herman R. Pathomorphological Characteristics and Pathogenesis of Viral Hepatitis. Pathol Oncol Res. 1996;2(3):117-131doi: 10.1007/BF02903516.
Schaff, Z., Lotz, G., & Schulte-Herman, R. (1996). Pathomorphological Characteristics and Pathogenesis of Viral Hepatitis. Pathology oncology research : POR, 2(3), 117-131. https://doi.org/10.1007/BF02903516
Schaff, Zsuzsa, et al. "Pathomorphological Characteristics and Pathogenesis of Viral Hepatitis." Pathology oncology research : POR vol. 2,3 (1996): 117-131. doi: https://doi.org/10.1007/BF02903516
Schaff Z, Lotz G, Schulte-Herman R. Pathomorphological Characteristics and Pathogenesis of Viral Hepatitis. Pathol Oncol Res. 1996;2(3):117-131. doi: 10.1007/BF02903516. PMID: 11173596.
Copy Download .nbib Format: NLM
Share it on

Pathol Oncol Res. 1996;2(3):117-131. doi: 10.1007/BF02903516.

Pathomorphological Characteristics and Pathogenesis of Viral Hepatitis.

Pathology oncology research : POR

Zsuzsa Schaff, Gábor Lotz, Rolf Schulte-Herman

Affiliations

  1. Semmelweis University of Medicine, 1st Institute of Pathology and Experimental Cancer Research, Budapest, Hungary.

PMID: 11173596 DOI: 10.1007/BF02903516

Abstract

Viral hepatitis (VH) is an inflammatory reaction of the liver to hepatotropic viruses. Acute VH can be classified according to the virus and type of necrosis. Chronic hepatitis (CH) might be active, persistent or lobular based on previous classification. More recently the grade (necroinflammatory activity) and stage (fibrosis and architectural distorsion) of CH have been distinguished and scored. Apoptosis and necrosis probably coexist in VH and contribute to hepatocyte death. Several "death factors", such as transforming growth factor b, Apo1/Fas and tumor necrosis factor play a role in the execution of cell death. Injury of hepatocytes during viral infection can occur as a direct effect of the virus or as a result of the host immune response. Expression of different viral antigens can be detected during VH and might be visualized. Phenotyping of the portal inflammatory cell infiltrate in CH has shown a T-cell zone comprised of CD4+ helper T cells and CD8+ supressor/cytotoxic T cells at the periphery of the lobules. The pathogenetic mechanisms responsible for the final outcome of viral infection depend on viral factors (such as genotype, mutation etc.), virus-host interaction, expression of viral protein, several cytokines etc. which finally lead to the well known histological alterations of viral hepatitis.

References

  1. Lancet. 1992 Jun 20;339(8808):1543 - PubMed
  2. Science. 1994 Mar 25;263(5154):1759-62 - PubMed
  3. Science. 1994 Jul 22;265(5171):528-30 - PubMed
  4. J Hepatol. 1992 Sep;16(1-2):219-23 - PubMed
  5. Cell. 1993 Dec 17;75(6):1169-78 - PubMed
  6. Dig Dis Sci. 1994 Feb;39(2):225-33 - PubMed
  7. Int J Clin Lab Res. 1991;21(2):199-201 - PubMed
  8. J Exp Med. 1995 Nov 1;182(5):1223-30 - PubMed
  9. J Hepatol. 1991 Nov;13(3):347-50 - PubMed
  10. Hepatology. 1995 Aug;22(2):418-25 - PubMed
  11. Hepatology. 1987 Jul-Aug;7(4):758-63 - PubMed
  12. Nature. 1995 Feb 2;373(6513):438-41 - PubMed
  13. Lab Invest. 1989 Jan;60(1):4-13 - PubMed
  14. Hepatology. 1992 Apr;15(4):567-71 - PubMed
  15. Hepatology. 1993 Nov;18(5):1238-46 - PubMed
  16. J Gen Virol. 1995 May;76 ( Pt 5):1215-21 - PubMed
  17. Hepatology. 1994 Sep;20(3):553-7 - PubMed
  18. Hepatology. 1992 Apr;15(4):572-7 - PubMed
  19. Nature. 1993 Feb 25;361(6414):739-42 - PubMed
  20. J Med Virol. 1993 Aug;40(4):291-306 - PubMed
  21. Hepatology. 1993 Mar;17(3):366-71 - PubMed
  22. Proc Natl Acad Sci U S A. 1992 Mar 15;89(6):2247-51 - PubMed
  23. Gastroenterology. 1992 Aug;103(2):622-9 - PubMed
  24. Proc Natl Acad Sci U S A. 1994 Feb 15;91(4):1294-8 - PubMed
  25. Dig Dis Sci. 1994 Dec;39(12):2660-4 - PubMed
  26. Biochem Biophys Res Commun. 1994 Oct 28;204(2):468-74 - PubMed
  27. Liver. 1994 Oct;14(5):251-6 - PubMed
  28. Hepatology. 1995 Aug;22(2):389-94 - PubMed
  29. Science. 1995 Mar 10;267(5203):1449-56 - PubMed
  30. Liver. 1988 Apr;8(2):80-7 - PubMed
  31. Gastroenterology. 1993 Apr;104(4):1122-8 - PubMed
  32. Hepatology. 1994 Jun;19(6):1354-9 - PubMed
  33. Hepatology. 1993 Dec;18(6):1344-9 - PubMed
  34. Gastroenterology. 1993 Feb;104(2):580-7 - PubMed
  35. Hepatology. 1995 Jul;22(1):30-5 - PubMed
  36. Hepatology. 1991 Dec;14(6):980-4 - PubMed
  37. Hepatology. 1995 Jun;21(6):1725-41 - PubMed
  38. Hepatology. 1994 Aug;20(2):275-86 - PubMed
  39. J Gen Virol. 1993 Nov;74 ( Pt 11):2391-9 - PubMed
  40. Hepatology. 1994 Dec;20(6):1399-404 - PubMed
  41. Am J Clin Pathol. 1994 Dec;102(6):746-51 - PubMed
  42. Hepatology. 1991 Dec;14(6):985-9 - PubMed
  43. J Hepatol. 1995 Jun;22(6):696-9 - PubMed
  44. Science. 1996 Jan 26;271(5248):505-8 - PubMed
  45. Hepatology. 1989 Dec;10(6):911-5 - PubMed
  46. Hepatology. 1994 Dec;20(6):1383-9 - PubMed
  47. Hepatology. 1991 Aug;14(2):269-73 - PubMed
  48. Hepatology. 1991 Jan;13(1):150-7 - PubMed
  49. Lancet. 1990 Aug 11;336(8711):325-9 - PubMed
  50. J Exp Med. 1993 Nov 1;178(5):1541-54 - PubMed
  51. J Med Virol. 1994 Mar;42(3):294-8 - PubMed
  52. Hum Pathol. 1994 Jul;25(7):644-51 - PubMed
  53. J Gen Virol. 1993 Jun;74 ( Pt 6):1103-13 - PubMed
  54. Hepatology. 1992 Sep;16(3):655-63 - PubMed
  55. Mol Genet Med. 1992;2:67-104 - PubMed
  56. Hepatology. 1988 Jan-Feb;8(1):98-103 - PubMed
  57. J Clin Invest. 1995 May;95(5):2067-75 - PubMed
  58. Br J Cancer. 1993 Mar;67(3):531-6 - PubMed
  59. Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):614-8 - PubMed
  60. Virology. 1990 Nov;179(1):113-20 - PubMed
  61. Lancet. 1992 Mar 28;339(8796):808 - PubMed
  62. Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2451-5 - PubMed
  63. Liver. 1990 Feb;10(1):17-27 - PubMed
  64. Am J Pathol. 1994 Mar;144(3):460-5 - PubMed
  65. J Biol Chem. 1992 May 25;267(15):10709-15 - PubMed
  66. J Infect Dis. 1991 Feb;163(2):400-2 - PubMed
  67. Hepatology. 1993 Aug;18(2):240-5 - PubMed
  68. Am J Surg Pathol. 1995 Dec;19(12):1409-17 - PubMed
  69. Hepatology. 1994 Jan;19(1):13-8 - PubMed
  70. J Hepatol. 1991;13 Suppl 4:S125-9 - PubMed
  71. Hepatology. 1995 Jul;22(1):10-9 - PubMed
  72. Hepatology. 1995 Aug;22(2):413-7 - PubMed
  73. Hepatology. 1994 Aug;20(2):349-55 - PubMed
  74. Gastroenterology. 1993 Sep;105(3):858-62 - PubMed
  75. J Gen Virol. 1992 Dec;73 ( Pt 12):3141-5 - PubMed
  76. Virology. 1989 Jan;168(1):40-7 - PubMed
  77. J Med Virol. 1994 Mar;42(3):268-71 - PubMed
  78. Gastroenterology. 1993 Feb;104(2):595-603 - PubMed
  79. Annu Rev Cell Biol. 1990;6:247-96 - PubMed
  80. Lancet. 1979 Oct 20;2(8147):827-8 - PubMed
  81. Liver. 1994 Jun;14(3):161-6 - PubMed
  82. Hepatology. 1992 Aug;16(2):306-11 - PubMed
  83. Proc Natl Acad Sci U S A. 1990 Sep;87(18):7140-4 - PubMed
  84. J Med Virol. 1994 Aug;43(4):380-5 - PubMed
  85. J Hepatol. 1991;13 Suppl 4:S116-8 - PubMed
  86. Liver. 1994 Oct;14(5):265-9 - PubMed
  87. Hepatology. 1994 Feb;19(2):265-72 - PubMed
  88. Lab Invest. 1991 Oct;65(4):408-11 - PubMed
  89. Hepatology. 1991 Mar;13(3):413-6 - PubMed
  90. Hepatology. 1991 May;13(5):845-51 - PubMed
  91. Pathol Res Pract. 1994 Nov;190(11):1017-25 - PubMed
  92. Gastroenterology. 1993 Apr;104(4):955-63 - PubMed
  93. Cancer. 1994 May 1;73(9):2253-8 - PubMed
  94. Hepatology. 1995 Oct;22(4 Pt 1):1021-6 - PubMed
  95. Liver. 1992 Aug;12(4 Pt 2):286-9 - PubMed
  96. Gastroenterology. 1993 Jul;105(1):274-8 - PubMed
  97. Liver. 1994 Apr;14(2):65-70 - PubMed
  98. Hepatology. 1994 Jun;19(6):1513-20 - PubMed
  99. Hepatology. 1995 Jul;22(1):1-9 - PubMed
  100. Hepatology. 1994 Aug;20(2):317-25 - PubMed
  101. Nature. 1990 Nov 22;348(6299):334-6 - PubMed
  102. J Immunol. 1992 Nov 15;149(10):3339-44 - PubMed
  103. Hepatology. 1981 Sep-Oct;1(5):431-5 - PubMed
  104. Lancet. 1977 Oct 29;2(8044):914-9 - PubMed
  105. Lancet. 1968 Sep 14;2(7568):626-8 - PubMed
  106. J Gen Virol. 1995 May;76 ( Pt 5):1205-14 - PubMed
  107. Am J Gastroenterol. 1994 Sep;89(9):1458-61 - PubMed
  108. Hepatology. 1994 Dec;20(6):1405-11 - PubMed

Publication Types