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Schwab M. MYCN Amplification in Neuroblastoma: a Paradigm for the Clinical Use of an Oncogene. Pathol Oncol Res. 1997;3(1):3-7doi: 10.1007/BF02893344.
Schwab, M. (1997). MYCN Amplification in Neuroblastoma: a Paradigm for the Clinical Use of an Oncogene. Pathology oncology research : POR, 3(1), 3-7. https://doi.org/10.1007/BF02893344
Schwab, Manfred. "MYCN Amplification in Neuroblastoma: a Paradigm for the Clinical Use of an Oncogene." Pathology oncology research : POR vol. 3,1 (1997): 3-7. doi: https://doi.org/10.1007/BF02893344
Schwab M. MYCN Amplification in Neuroblastoma: a Paradigm for the Clinical Use of an Oncogene. Pathol Oncol Res. 1997;3(1):3-7. doi: 10.1007/BF02893344. PMID: 11173617.
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Pathol Oncol Res. 1997;3(1):3-7. doi: 10.1007/BF02893344.

MYCN Amplification in Neuroblastoma: a Paradigm for the Clinical Use of an Oncogene.

Pathology oncology research : POR

Manfred Schwab

Affiliations

  1. German Cancer Research Center, Division of Cytogenetics, Heidelberg, Germany.

PMID: 11173617 DOI: 10.1007/BF02893344

Abstract

Increase of the dosage of cellular oncogenes by DNA amplification is a frequent genetic alteration of cancer cells. The presence of amplified cellular oncogenes is usually signalled by conspicuous chromosomal abnormalities, "double minutes" (DMs) or "homogeneously staining chromsomal regions" (HSRs). Some human cancers carry a specific amplified oncogene at high incidence. In neuroblastomas the amplification of MYCN has been found associated with aggressively growing cancers and is an indicator for poor prognosis. MYCN amplification is of predictive value for identifying neuroblastoma patiens that require specific therapeutic regimens and for identifying patients that will not benefit from chemotherapy.

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