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Jablonska E, Piotrowski L, Grabowska Z. Serum Levels of IL-1b, IL-6, TNF-a, sTNF-RI and CRP in Patients with Oral Cavity Cancer. Pathol Oncol Res. 1997;3(2):126-129doi: 10.1007/BF02907807.
Jablonska, E., Piotrowski, L., & Grabowska, Z. (1997). Serum Levels of IL-1b, IL-6, TNF-a, sTNF-RI and CRP in Patients with Oral Cavity Cancer. Pathology oncology research : POR, 3(2), 126-129. https://doi.org/10.1007/BF02907807
Jablonska, Ewa, et al. "Serum Levels of IL-1b, IL-6, TNF-a, sTNF-RI and CRP in Patients with Oral Cavity Cancer." Pathology oncology research : POR vol. 3,2 (1997): 126-129. doi: https://doi.org/10.1007/BF02907807
Jablonska E, Piotrowski L, Grabowska Z. Serum Levels of IL-1b, IL-6, TNF-a, sTNF-RI and CRP in Patients with Oral Cavity Cancer. Pathol Oncol Res. 1997;3(2):126-129. doi: 10.1007/BF02907807. PMID: 11173639.
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Pathol Oncol Res. 1997;3(2):126-129. doi: 10.1007/BF02907807.

Serum Levels of IL-1b, IL-6, TNF-a, sTNF-RI and CRP in Patients with Oral Cavity Cancer.

Pathology oncology research : POR

Ewa Jablonska, Leszek Piotrowski, Zyta Grabowska

Affiliations

  1. Medical Academy, Department of Immmunopathology, Bialystok, Poland.

PMID: 11173639 DOI: 10.1007/BF02907807

Abstract

Pro-inflammatory cytokines, such as interleukin-1b (IL-1b), interleukin-6 (IL-6) and tumor necrosis factor- (TNF-a) play an essential role in the regulation of immune response to, and may have prognostic significance in, cancer. The aim of this study was to examine the relationship between the serum levels of IL-1b, IL-6 and TNF-a as well as the concentrations of soluble TNF receptor I (sTNF-RI) and C-reactive protein (CRP) in patients with squamous cell carcinoma of oral cavity. Results obtained were confronted with squamous cell carcinoma antigen (SCC) concentrations. IL-1b IL-6 and TNF-a serum levels as well as sTNF-RI and CRP concentrations were higher in patients than in controls. The increased serum levels appeared to be related to the clinical stage of disease. There was a correlation between IL-1b and sTNF-RI. IL-6 and IL-1b correlated with CRP levels. The mean concentrations of SCC were also elevated. IL-6 and sTNF-RI seemed to be the most sensitive parameters in early stages and may be used as additional markers in oral cancer.

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