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Gessler F, Behrens S, Loch P, et al. Entwicklung eines in vitro Tests zum Botulinum-Toxinnachweis - erste Ergebnisse. [Development of an in vitro assay for the detection of Botulinum Neurotoxins]. ALTEX. 1998;15(5):62-64
Gessler, F., Behrens, S., Loch, P., & Böhnel, H. (1998). Entwicklung eines in vitro Tests zum Botulinum-Toxinnachweis - erste Ergebnisse. [Development of an in vitro assay for the detection of Botulinum Neurotoxins]. ALTEX, 15(5), 62-64.
Gessler, Frank, et al. "Entwicklung eines in vitro Tests zum Botulinum-Toxinnachweis - erste Ergebnisse." [Development of an in vitro assay for the detection of Botulinum Neurotoxins]. ALTEX vol. 15,5 (1998): 62-64.
Gessler F, Behrens S, Loch P, Böhnel H. Entwicklung eines in vitro Tests zum Botulinum-Toxinnachweis - erste Ergebnisse. [Development of an in vitro assay for the detection of Botulinum Neurotoxins]. ALTEX. 1998;15(5):62-64. PMID: 11178545.
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ALTEX. 1998;15(5):62-64.

[Development of an in vitro assay for the detection of Botulinum Neurotoxins].

ALTEX

Frank Gessler, Susanne Behrens, Petra Loch, Helge Böhnel

Affiliations

  1. Institut für Pflanzenbau und Tierproduktion in den Tropen und Subtropen, Bereich Tierhygiene, Georg-August-Universität, D-Göttingen.

PMID: 11178545

Abstract

Botulism is a severe, often lethal intoxication, which affects man and animal. It is caused by the neurotoxins (BoNT) of Clostridium botulinum, an anaerobic spore-former. At present the toxin types A-G have been identified. The extreme toxicity of these substances still make the animal testing inevitable. No alternative method could reach the sensitivity of the mouse bioassay. Based on the investigations presented, a serological test shall be developed, which concentrates the sample and detects the toxin in one step. Preliminary results of an in vitro test detecting BoNT/D are discussed.

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