Display options
Cite
Kohno N, Kitazawa S, Sakoda Y, et al. Parathyroid Hormone-related Protein in Breast Cancer Tissues: Relationship between Primary and Metastatic Sites. Breast Cancer. 1994;1(1):43-49doi: 10.1007/BF02967374.
Kohno, N., Kitazawa, S., Sakoda, Y., Kanbara, Y., Furuya, Y., Ohashi, O., & Kitazawa, R. (1994). Parathyroid Hormone-related Protein in Breast Cancer Tissues: Relationship between Primary and Metastatic Sites. Breast cancer (Tokyo, Japan), 1(1), 43-49. https://doi.org/10.1007/BF02967374
Kohno, et al. "Parathyroid Hormone-related Protein in Breast Cancer Tissues: Relationship between Primary and Metastatic Sites." Breast cancer (Tokyo, Japan) vol. 1,1 (1994): 43-49. doi: https://doi.org/10.1007/BF02967374
Kohno N, Kitazawa S, Sakoda Y, Kanbara Y, Furuya Y, Ohashi O, Kitazawa R. Parathyroid Hormone-related Protein in Breast Cancer Tissues: Relationship between Primary and Metastatic Sites. Breast Cancer. 1994 Jul 30;1(1):43-49. doi: 10.1007/BF02967374. PMID: 11091506.
Copy Download .nbib Format: NLM
Share it on

Breast Cancer. 1994 Jul 30;1(1):43-49. doi: 10.1007/BF02967374.

Parathyroid Hormone-related Protein in Breast Cancer Tissues: Relationship between Primary and Metastatic Sites.

Breast cancer (Tokyo, Japan)

Kohno, Kitazawa, Sakoda, Kanbara, Furuya, Ohashi, Kitazawa

Affiliations

  1. Departments of Surgery, Hyogo Medical Center for Adults, 1-7 Kitaoji-cho, Akashi 651, Japan.

PMID: 11091506 DOI: 10.1007/BF02967374

Abstract

The expression of parathyroid hormone-related protein (PTHrP) at primary and metastatic sites was studied retrospectively in specimens obtained at opreation and autopsy from 11 patients. The anti-human PTHrP monoclonal antibody, 4B3, was used in the immunohistochemical studies. The 11 cases showed metastases to the liver and the lung, and 9 showed bone metastases at autopsy. At primary sites, PTHrP was positive in the 9 cases with bone metastases, while the other 2 cases were negative for PTHrP. Regardless of the intensities of immunohistochemical staining of PTHrP at primary sites, cancer cells at metastatic sites in the liver and the lung were almost all negative for PTHrP. On the other hand, all PTHrP-positive cases at primary sites at operation showed skeletal metastases at autopsy, and the intensity of the immunohistochemical staining of PTHrP was strongly positive at all the sites of skeletal metastasis. These results suggest that while PTHrP is an important factor that causes cancer cells to erode and grow in skeletal bone, the expression of PHTrP is, concurrently, affected by an osseous microenvironment.

References

  1. Cancer Res. 1991 Dec 15;51(24):6521-8 - PubMed
  2. Surg Today. 1994;24(3):215-20 - PubMed
  3. Biochem Biophys Res Commun. 1987 Jul 31;146(2):672-8 - PubMed
  4. Cancer Res. 1987 Feb 1;47(3):707-12 - PubMed
  5. Cancer Res. 1990 Dec 1;50(23):7710-6 - PubMed
  6. J Clin Invest. 1991 Mar;87(3):884-93 - PubMed
  7. Cancer. 1991 Feb 15;67(4):984-9 - PubMed
  8. J Clin Endocrinol Metab. 1982 Dec;55(6):1066-72 - PubMed
  9. Eur J Cancer. 1991;27(12):1552-5 - PubMed
  10. Endocrinology. 1989 Jul;125(1):563-5 - PubMed
  11. Eur J Cancer. 1991;27(3):236-9 - PubMed
  12. Science. 1987 Aug 21;237(4817):893-6 - PubMed
  13. Proc Natl Acad Sci U S A. 1988 Jan;85(2):597-601 - PubMed
  14. J Clin Invest. 1985 Aug;76(2):391-4 - PubMed
  15. J Clin Invest. 1987 Dec;80(6):1803-7 - PubMed
  16. Nature. 1976 Oct 7;263(5577):507-8 - PubMed
  17. Br Med J. 1973 Dec 15;4(5893):643-6 - PubMed
  18. Nature. 1975 Aug 7;256(5517):495-7 - PubMed
  19. J Bone Miner Res. 1989 Dec;4(6):839-44 - PubMed
  20. Am J Clin Pathol. 1966 Mar;45(3):290-6 - PubMed
  21. Surg Forum. 1960;11:70-1 - PubMed
  22. Br Med J (Clin Res Ed). 1987 Oct 31;295(6606):1093-6 - PubMed
  23. Cancer Res. 1991 Jun 1;51(11):3059-61 - PubMed
  24. Cancer Res. 1989 Jul 15;49(14):3849-52 - PubMed

Publication Types