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Kato T, Kimura T, Takami N, et al. New Prognostic Factors Associated with Long-term Survival in Node-Negative Breast Cancer Patients. Breast Cancer. 1999;6(4):370-377doi: 10.1007/BF02966456.
Kato, T., Kimura, T., Takami, N., Miyakawa, R., Tanaka, S., Muraki, H., Kamio, T., Fujii, A., Yamamoto, K., Kameoka, S., Nishikawa, T., & Kasajima, T. (1999). New Prognostic Factors Associated with Long-term Survival in Node-Negative Breast Cancer Patients. Breast cancer (Tokyo, Japan), 6(4), 370-377. https://doi.org/10.1007/BF02966456
Kato, et al. "New Prognostic Factors Associated with Long-term Survival in Node-Negative Breast Cancer Patients." Breast cancer (Tokyo, Japan) vol. 6,4 (1999): 370-377. doi: https://doi.org/10.1007/BF02966456
Kato T, Kimura T, Takami N, Miyakawa R, Tanaka S, Muraki H, Kamio T, Fujii A, Yamamoto K, Kameoka S, Nishikawa T, Kasajima T. New Prognostic Factors Associated with Long-term Survival in Node-Negative Breast Cancer Patients. Breast Cancer. 1999 Oct 25;6(4):370-377. doi: 10.1007/BF02966456. PMID: 11091746.
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Breast Cancer. 1999 Oct 25;6(4):370-377. doi: 10.1007/BF02966456.

New Prognostic Factors Associated with Long-term Survival in Node-Negative Breast Cancer Patients.

Breast cancer (Tokyo, Japan)

Kato, Kimura, Takami, Miyakawa, Tanaka, Muraki, Kamio, Fujii, Yamamoto, Kameoka, Nishikawa, Kasajima

Affiliations

  1. Departments of Surgery II, School of Medicine, Tokoy Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.

PMID: 11091746 DOI: 10.1007/BF02966456

Abstract

BACKGROUND: This study was undertaken to determine the absolute and relative value of angiogenesis, proliferating cell nuclear antigen (PCNA) and conventional prognostic factors in predicting relapse-free survival (RFS) and overall survival (OS) rates associated with long-term survival in Japanese patients with node-negative breast cancer. PATIENTS AND METHODS: Two hundred patients with histological node-negative breast cancer were studied. We investigated nine clinicopathological factors, including angiogenesis, PCNA using per-manent-section immunohistochemistry, clinicaltumor size, histological grade (HG), tumor necrosis, lymphatic vessel invasion (LVI), histological extension, histological classification, and infiltrating growth (INF), followed for a median of 10 years (range, 1 to 20). RESULTS: Twenty-one patients (10.5%) had recurrence and 15 patients (7.5%) died of breast cancer. Univariate analysis showed that PCNA, clinical tumor size, HG, angiogenesis, and LVI were significantly predictive of 20-year RFS or OS. Tumor necrosis was significantly predictive of OS, not of RFS. Multi-variate analysis showed that clinical tumor size (P = 0.0003), angiogenesis (P = 0.0003), PCNA (P = 0.0064), and HG (P = 0.0401) were significant independent prognostic factors for RFS. PCNA (P< 0.0001) and clinical tumor size (P = 0.0112) were significant independent prognostic factors for OS, while angiogenesis was a borderline significant factor. CONCLUSION: PCNA and angiogenesis were important new prognostic factors in node-negative breast cancer patients.

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