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Spear DJ, Hienz RD, Brady JV. Acute opioid administration effects on sensory and motor function in baboons: buprenorphine, morphine, and naloxone. Behav Pharmacol. 1992;3(1):31-42doi: 10.1097/00008877-199203010-00006.
Spear, D. J., Hienz, R. D., & Brady, J. V. (1992). Acute opioid administration effects on sensory and motor function in baboons: buprenorphine, morphine, and naloxone. Behavioural pharmacology, 3(1), 31-42. https://doi.org/10.1097/00008877-199203010-00006
Spear, D.J., et al. "Acute opioid administration effects on sensory and motor function in baboons: buprenorphine, morphine, and naloxone." Behavioural pharmacology vol. 3,1 (1992): 31-42. doi: https://doi.org/10.1097/00008877-199203010-00006
Spear DJ, Hienz RD, Brady JV. Acute opioid administration effects on sensory and motor function in baboons: buprenorphine, morphine, and naloxone. Behav Pharmacol. 1992 Feb;3(1):31-42. doi: 10.1097/00008877-199203010-00006. PMID: 11224099.
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Behav Pharmacol. 1992 Feb;3(1):31-42. doi: 10.1097/00008877-199203010-00006.

Acute opioid administration effects on sensory and motor function in baboons: buprenorphine, morphine, and naloxone.

Behavioural pharmacology

D.J. Spear, R.D. Hienz, J.V. Brady

Affiliations

  1. The Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Division of Behavioral Biology, 720 Rutland Avenue, 624 Traylor Building, Baltimore, MD 21205, USA.

PMID: 11224099 DOI: 10.1097/00008877-199203010-00006

Abstract

The effects of acute administration of the opioid compounds buprenorphine, morphine, and naloxone were studied on auditory and visual threshold functions and reaction time performances in baboons. Baboons were trained in a reaction time procedure to hold a lever depressed, and release the lever when a signal was presented. Auditory and visual signals were employed in separate sessions. Drug was administered 30min prior to testing. Dose-related increases in visual and auditory thresholds were observed following buprenorphine, with visual thresholds being somewhat more drug-sensitive. Buprenorphine also increased reaction times to both high-intensity and low-intensity stimuli. High doses of morphine increased reaction times to high-intensity auditory and low-intensity visual stimuli; thresholds for both modalities were unaffected by any dose of morphine. Naloxone produced no consistent effects on thresholds or reaction times. False alarm rates were not significantly changed by buprenorphine, morphine, or naloxone.

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