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Broadbent J, Appel JB, Michael EK, et al. Discriminative stimulus effects of the optical isomers of 3,4-methylenedioxyamphetamine (MDA). Behav Pharmacol. 1992;3(5):443-454
Broadbent, J., Appel, J. B., Michael, E. K., & Ricker, J. H. (1992). Discriminative stimulus effects of the optical isomers of 3,4-methylenedioxyamphetamine (MDA). Behavioural pharmacology, 3(5), 443-454.
Broadbent, J., et al. "Discriminative stimulus effects of the optical isomers of 3,4-methylenedioxyamphetamine (MDA)." Behavioural pharmacology vol. 3,5 (1992): 443-454.
Broadbent J, Appel JB, Michael EK, Ricker JH. Discriminative stimulus effects of the optical isomers of 3,4-methylenedioxyamphetamine (MDA). Behav Pharmacol. 1992 Oct;3(5):443-454. PMID: 11224147.
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Behav Pharmacol. 1992 Oct;3(5):443-454.

Discriminative stimulus effects of the optical isomers of 3,4-methylenedioxyamphetamine (MDA).

Behavioural pharmacology

J. Broadbent, J.B. Appel, E.K. Michael, J.H. Ricker

Affiliations

  1. Behavioral Pharmacology Laboratory, Department of Psychology, University of South Carolina, Columbia, SC 29208, USA.

PMID: 11224147

Abstract

The isomers of 3,4-methylenedioxyamphetamine (MDA) functioned as discriminative stimuli in rats trained to discriminate either (-) MDA (1.25mg/kg) or (+) MDA (1.25mg/kg) from saline. Dose- and time-response curves indicated that drug lever selection occurred at doses of at least 1.00mg/kg of (-) MDA and 0.75mg/kg of (+) MDA and that drug-appropriate responding for both isomers was maintained for at least 90min. Cross-substitution was observed between the MDA isomers; both (+) and (-) 3,4-methylenedioxymethamphetamine (MDMA) also substituted completely for (+) and (-) MDA. The hallucinogens (+)-lysergic acid diethylamide (LSD) and (+/-)-2,5-dimethoxy-4-methylamphetamine (DOM), substituted for (-) MDA; neither mescaline nor (+) amphetamine or cocaine had (-) MDA-like effects. LSD also substituted for (+) MDA; DOM, mescaline, (+) amphetamine and cocaine failed to have (+) MDA-like effects. The (-) but not the (+) MDA cue was blocked by the 5-HT(2) antagonist pirenpirone; the dopamine (DA) antagonists SCH-23390 and (-) sulpiride had no effect on either the (-) or (+) MDA cues. When animals were trained to discriminate LSD (0.16mg/kg) or (+) amphetamine (1.0mg/kg) from saline, neither (-) MDA nor (+) MDA substituted completely. These results indicate that: (1) the stimulus effects of the isomers of MDA and MDMA are similar; (2) (-) MDA may be more hallucinogenic (or more accurately, LSD- or DOM-like) than (+) MDA; (3) neither (+) nor (-) MDA has potent amphetamine-like effects; and (4) the effects of (-) MDA may be more serotonergic than those of (+) MDA.

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