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Torres MC, Morales A, Megías JL, et al. Flumazenil antagonizes the effect of diazepam on negative contrast in one-way avoidance learning. Behav Pharmacol. 1994;5(6):637-641doi: 10.1097/00008877-199410000-00010.
Torres, M. C., Morales, A., Megías, J. L., Cándido, A., & Maldonado, A. (1994). Flumazenil antagonizes the effect of diazepam on negative contrast in one-way avoidance learning. Behavioural pharmacology, 5(6), 637-641. https://doi.org/10.1097/00008877-199410000-00010
Torres, M.C., et al. "Flumazenil antagonizes the effect of diazepam on negative contrast in one-way avoidance learning." Behavioural pharmacology vol. 5,6 (1994): 637-641. doi: https://doi.org/10.1097/00008877-199410000-00010
Torres MC, Morales A, Megías JL, Cándido A, Maldonado A. Flumazenil antagonizes the effect of diazepam on negative contrast in one-way avoidance learning. Behav Pharmacol. 1994 Oct;5(6):637-641. doi: 10.1097/00008877-199410000-00010. PMID: 11224244.
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Behav Pharmacol. 1994 Oct;5(6):637-641. doi: 10.1097/00008877-199410000-00010.

Flumazenil antagonizes the effect of diazepam on negative contrast in one-way avoidance learning.

Behavioural pharmacology

M.C. Torres, A. Morales, J.L. Megías, A. Cándido, A. Maldonado

Affiliations

  1. Departamento de Psicología Experimental y Fisiología del Comportamiento and Instituto de Neurociencias "F. Olóriz", Campus Cartuja, Universidad de Granada, 18071-Granada, Spain.

PMID: 11224244 DOI: 10.1097/00008877-199410000-00010

Abstract

The main aim of the present work was to study whether the effect of diazepam upon successive negative contrast in one-way avoidance learning-induced by shifting rats from a large reward (30s spent in the safe compartment) to a small reward (1s)-is mediated by the action of this drug on the benzodiazepine (BZ) receptor. Therefore, we studied the influence of flumazenil (FL), a BZ antagonist, on the effect of diazepam (DZ) on negative contrast. The i.p. administration of 5 and 12mg/kg, but not of 2mg/kg of FL, reliably antagonized the abolition by DZ (1mg/kg) on successive negative contrast. Moreover, FL (12mg/kg) did not affect either the avoidance response or the contrast effect. These results suggest that the GABA system is involved in the successive negative contrast effect in one-way avoidance learning, and that this experimental procedure may be useful in studies of anti-anxiety agents.

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