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Chemla D, Coirault C, Hébert JL, et al. Mechanics of Relaxation of the Human Heart. News Physiol Sci. 2000;15:78-83doi: 10.1152/physiologyonline.2000.15.2.78.
Chemla, D., Coirault, C., Hébert, J. L., & Lecarpentier, Y. (2000). Mechanics of Relaxation of the Human Heart. News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society, 1578-83. https://doi.org/10.1152/physiologyonline.2000.15.2.78
Chemla, Denis, et al. "Mechanics of Relaxation of the Human Heart." News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society vol. 15 (2000): 78-83. doi: https://doi.org/10.1152/physiologyonline.2000.15.2.78
Chemla D, Coirault C, Hébert JL, Lecarpentier Y. Mechanics of Relaxation of the Human Heart. News Physiol Sci. 2000 Apr;15:78-83. doi: 10.1152/physiologyonline.2000.15.2.78. PMID: 11390883.
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News Physiol Sci. 2000 Apr;15:78-83. doi: 10.1152/physiologyonline.2000.15.2.78.

Mechanics of Relaxation of the Human Heart.

News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society

Denis Chemla, Catherine Coirault, Jean-Louis Hébert, Yves Lecarpentier

Affiliations

  1. Service de Physiologie Cardio-Respiratoire, CHU de Bicêtre, Assistance Publique-Hôpitaux de Paris, 94 275 Le Kremlin-Bicêtre, and Unité Inserm U451-Loa-Ensta-Ecole Polytechnique, 91 125 Palaiseau, France.

PMID: 11390883 DOI: 10.1152/physiologyonline.2000.15.2.78

Abstract

Rapid and complete relaxation is a prerequisite for cardiac output adaptation to changes in loading conditions, inotropic stimulation, and heart rate. In the healthy human heart, the rate and extent of relaxation depend mainly on actomyosin cross bridge dissociation and on left ventricular end-systolic volume, rather than on the afterload level.

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