News Physiol Sci. 2000 Apr;15:89-93. doi: 10.1152/physiologyonline.2000.15.2.89.
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society
Peter J. Meier, Bruno Stieger
PMID: 11390885 DOI: 10.1152/physiologyonline.2000.15.2.89
Active canalicular secretion of bile salts and non-bile salt organic anions represents the major driving force of hepatic bile formation. The most important carriers involved have now been cloned on both the basolateral and canalicular sides of hepatocytes. Elucidation of their structure, transport properties, and regulation is an important step forward in the ultimate understanding of the molecular physiology of bile formation.