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News Physiol Sci. 2000 Dec;15:284-290. doi: 10.1152/physiologyonline.2000.15.6.284.

GABA in the Mammalian Enteric Nervous System.

News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society

Anthony Krantis

Affiliations

  1. Department of Cellular and Molecular Medicine, Digestive Diseases Research Group, University of Ottawa, Ottawa, ON, Canada K1H 8M5.

PMID: 11390928 DOI: 10.1152/physiologyonline.2000.15.6.284

Abstract

gamma-Aminobutyric acid (GABA) is a transmitter of enteric interneurons, targeting excitatory GABA(A) or inhibitory GABA(B) receptors that modulate motility and mucosal function. Enteric GABA may also subserve hormonal and paracrine signaling. Disruption in gastrointestinal function following perturbation of enteric GABA receptors presents potential new target sites for drug development.

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