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Czarnecka E, Kubik-Bogucka E, Strzelec JS. Interaction between central effects of ethanol and melatonin in mice. Neuro Endocrinol Lett. 1999;20(6):379-383
Czarnecka, E., Kubik-Bogucka, E., & Strzelec, J. S. (1999). Interaction between central effects of ethanol and melatonin in mice. Neuro endocrinology letters, 20(6), 379-383.
Czarnecka, Elzbieta, et al. "Interaction between central effects of ethanol and melatonin in mice." Neuro endocrinology letters vol. 20,6 (1999): 379-383.
Czarnecka E, Kubik-Bogucka E, Strzelec JS. Interaction between central effects of ethanol and melatonin in mice. Neuro Endocrinol Lett. 1999;20(6):379-383. PMID: 11458202.
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Neuro Endocrinol Lett. 1999;20(6):379-383.

Interaction between central effects of ethanol and melatonin in mice.

Neuro endocrinology letters

Elzbieta Czarnecka, Elzbieta Kubik-Bogucka, Jaroslaw S. Strzelec

Affiliations

  1. Department of Pharmacodynamics, Medical University, Lódz, Poland.

PMID: 11458202

Abstract

Effects of melatonin on acute toxicity of ethanol and ethanol-induced hypothermia, ethanol and thiopental sleeping time and ethanol-induced hypermotility were investigated in mice. The melatonin (1 and 5 mg/kg) was injected i.p. in single or repeated doses (7 days). The experiments were performed during the light phase of the light/dark cycle. It has been shown that a single dose of melatonin shortened duration of ethanol sleep and decreased ethanol-induced hyperactivity in mice. Melatonin given to mice for 7 days did not influence ethanol-induced effects. Melatonin prolonged thiopental hypnotic effect. The results of central interaction of ethanol and melatonin may be of antagonistic or synergistic nature.

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