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Omagari K, Matsuo I, Ohba K, et al. Synchronized disappearance of serum HCV-RNA, anti-U1 RNP, anti-La/SS-B, and anti-Scl-70 in a patient with chronic hepatitis. Hepatol Res. 2001;19(3):263-269doi: 10.1016/s1386-6346(00)00114-5.
Omagari, K., Matsuo, I., Ohba, K., Masuda, J., Hazama, H., Sakimura, K., Kinoshita, H., Tsurutani, H., Isomoto, H., Murase, K., & Kohno, S. (2001). Synchronized disappearance of serum HCV-RNA, anti-U1 RNP, anti-La/SS-B, and anti-Scl-70 in a patient with chronic hepatitis. Hepatology research : the official journal of the Japan Society of Hepatology, 19(3), 263-269. https://doi.org/10.1016/s1386-6346(00)00114-5
Omagari, K, et al. "Synchronized disappearance of serum HCV-RNA, anti-U1 RNP, anti-La/SS-B, and anti-Scl-70 in a patient with chronic hepatitis." Hepatology research : the official journal of the Japan Society of Hepatology vol. 19,3 (2001): 263-269. doi: https://doi.org/10.1016/s1386-6346(00)00114-5
Omagari K, Matsuo I, Ohba K, Masuda J, Hazama H, Sakimura K, Kinoshita H, Tsurutani H, Isomoto H, Murase K, Kohno S. Synchronized disappearance of serum HCV-RNA, anti-U1 RNP, anti-La/SS-B, and anti-Scl-70 in a patient with chronic hepatitis. Hepatol Res. 2001 Mar 26;19(3):263-269. doi: 10.1016/s1386-6346(00)00114-5. PMID: 11251309.
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Hepatol Res. 2001 Mar 26;19(3):263-269. doi: 10.1016/s1386-6346(00)00114-5.

Synchronized disappearance of serum HCV-RNA, anti-U1 RNP, anti-La/SS-B, and anti-Scl-70 in a patient with chronic hepatitis.

Hepatology research : the official journal of the Japan Society of Hepatology

K Omagari, I Matsuo, K Ohba, J -i. Masuda, H Hazama, K Sakimura, H Kinoshita, H Tsurutani, H Isomoto, K Murase, S Kohno

Affiliations

  1. The Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan

PMID: 11251309 DOI: 10.1016/s1386-6346(00)00114-5

Abstract

The authors report a rare case of chronic hepatitis in whom normalization of serum aminotransferases was associated with disappearance of serum hepatitic C virus (HCV)-ribonucleic acid (RNA), anti-U1 RNP, anti-La/SS-B, and anti-Scl-70 antibodies without treatment of interferon or corticosteroids. A 27-year-old Japanese woman was diagnosed with chronic hepatitis C, with positive anti-nuclear antibody, anti-U1 RNP, anti-La/SS-B, and anti-Scl-70 antibodies. Histopathologic examination of a liver biopsy specimen showed a periportal interface hepatitis with a predominantly lymphoplasmacytic necroinflammatory infiltrate and lobular hepatitis. After two-year treatment with ursodeoxycholic acid (UDCA), serum aminotransferases normalized and serum HCV-RNA, anti-U1 RNP, anti-La/SS-B, and anti-Scl-70 antibodies disappeared. It was unclear whether disappearance of HCV-RNA was spontaneous, due to some immunomodulating effects of UDCA, or other unknown mechanism, but host immune response may be associated with HCV elimination.

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