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Rabin RA, Doat M, Winter JC. Role of serotonergic 5-HT2A receptors in the psychotomimetic actions of phencyclidine. Int J Neuropsychopharmacol. 2000;3(4):333-338doi: 10.1017/S1461145700002091.
Rabin, R. A., Doat, M., & Winter, J. C. (2000). Role of serotonergic 5-HT2A receptors in the psychotomimetic actions of phencyclidine. The international journal of neuropsychopharmacology, 3(4), 333-338. https://doi.org/10.1017/S1461145700002091
Rabin, Richard A., et al. "Role of serotonergic 5-HT2A receptors in the psychotomimetic actions of phencyclidine." The international journal of neuropsychopharmacology vol. 3,4 (2000): 333-338. doi: https://doi.org/10.1017/S1461145700002091
Rabin RA, Doat M, Winter JC. Role of serotonergic 5-HT2A receptors in the psychotomimetic actions of phencyclidine. Int J Neuropsychopharmacol. 2000 Dec;3(4):333-338. doi: 10.1017/S1461145700002091. PMID: 11343613.
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Int J Neuropsychopharmacol. 2000 Dec;3(4):333-338. doi: 10.1017/S1461145700002091.

Role of serotonergic 5-HT2A receptors in the psychotomimetic actions of phencyclidine.

The international journal of neuropsychopharmacology

Richard A. Rabin, Mireille Doat, Jerrold C. Winter

PMID: 11343613 DOI: 10.1017/S1461145700002091

Abstract

The psychotomimetic phencyclidine (PCP) alters various behavioural responses involving the serotonergic system including potentiating the discriminative stimulus effects of the phenethylamine hallucinogen, 2,5-dimethoxy-4-methylamphetamine (DOM). The present study was undertaken to test the hypothesis that PCP directly interacts with the 5-HT2A receptor. PC12 cells, a neuronal cell line, were stably transfected with the cDNA encoding the rat 5-HT2A receptor (PC12-5-HT2A). In these cells PCP and the related compounds, ketamine and dizocilpine, did not increase [3H]inositol phosphate generation nor did they alter 5-HT-stimulated phosphoinositide hydrolysis. These compounds also did not display appreciable affinity for the 5-HT2A receptor labelled with [3H]ketanserin. The present study indicates that the behavioural responses to PCP, ketamine and dizocilpine do not involve a direct interaction of these compounds with the 5-HT2A receptor.

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