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Sivridis E, Buckley CH, Fox H. An immunohistochemical study of the incidence and significance of carcinoembryonic antigen in malignant endometrium. Int J Gynecol Cancer. 1995;5(3):204-210doi: 10.1046/j.1525-1438.1995.05030204.x.
Sivridis, E., Buckley, C. H., & Fox, H. (1995). An immunohistochemical study of the incidence and significance of carcinoembryonic antigen in malignant endometrium. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 5(3), 204-210. https://doi.org/10.1046/j.1525-1438.1995.05030204.x
Sivridis, E., et al. "An immunohistochemical study of the incidence and significance of carcinoembryonic antigen in malignant endometrium." International journal of gynecological cancer : official journal of the International Gynecological Cancer Society vol. 5,3 (1995): 204-210. doi: https://doi.org/10.1046/j.1525-1438.1995.05030204.x
Sivridis E, Buckley CH, Fox H. An immunohistochemical study of the incidence and significance of carcinoembryonic antigen in malignant endometrium. Int J Gynecol Cancer. 1995 May;5(3):204-210. doi: 10.1046/j.1525-1438.1995.05030204.x. PMID: 11578478.
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Int J Gynecol Cancer. 1995 May;5(3):204-210. doi: 10.1046/j.1525-1438.1995.05030204.x.

An immunohistochemical study of the incidence and significance of carcinoembryonic antigen in malignant endometrium.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

E. Sivridis, C.H. Buckley, H. Fox

Affiliations

  1. Department of Pathological Sciences, University of Manchester; and Department of Reproductive Pathology, St Mary's Hospital, Manchester, UK.

PMID: 11578478 DOI: 10.1046/j.1525-1438.1995.05030204.x

Abstract

In an immunohistochemical study of the presence of carcinoembryonic antigen (CEA) in endometrial carcinomas, it was found that CEA was detectable in 92 of 171 neoplasms, an incidence of 53.8%. The antigen was unrelated to important prognostic variables, both clinical and histopathologic, and overall there was no difference in survival rates between CEA-positive and CEA-negative endometrial neoplasms during the 10-year follow-up period. CEA-negative carcinomas did, however, confer longer survival in certain subgroups of patients: those with adenocarcinomas arising from a hyperplastic endometrium, those with neoplasms of poor differentiation, and those who, in addition to surgery, received irradiation treatment. It is suggested that immunoperoxidase staining for CEA may provide an independent method for predicting radiosensitivity in endometrial carcinomas, and also may be indicative of prognosis within some forms of this malignancy.

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