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Brissaud O, Palin K, Chateil JF, et al. Sclérose en plaques: pathogénie et formes de révélation chez l'enfant. [Multiple sclerosis: pathogenesis and manifestations in children]. Arch Pediatr. 2001;8(9):969-78doi: 10.1016/s0929-693x(01)00564-4.
Brissaud, O., Palin, K., Chateil, J. F., & Pedespan, J. M. (2001). Sclérose en plaques: pathogénie et formes de révélation chez l'enfant. [Multiple sclerosis: pathogenesis and manifestations in children]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 8(9), 969-78. https://doi.org/10.1016/s0929-693x(01)00564-4
Brissaud, O, et al. "Sclérose en plaques: pathogénie et formes de révélation chez l'enfant." [Multiple sclerosis: pathogenesis and manifestations in children]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie vol. 8,9 (2001): 969-78. doi: https://doi.org/10.1016/s0929-693x(01)00564-4
Brissaud O, Palin K, Chateil JF, Pedespan JM. Sclérose en plaques: pathogénie et formes de révélation chez l'enfant. [Multiple sclerosis: pathogenesis and manifestations in children]. Arch Pediatr. 2001 Sep;8(9):969-78. doi: 10.1016/s0929-693x(01)00564-4. French. PMID: 11582940.
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Arch Pediatr. 2001 Sep;8(9):969-78. doi: 10.1016/s0929-693x(01)00564-4.

[Multiple sclerosis: pathogenesis and manifestations in children].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie

[Article in French]
O Brissaud, K Palin, J F Chateil, J M Pedespan

Affiliations

  1. Unité de neuropédiatrie, centre hospitalier universitaire Pellegrin, hôpital des enfants, place Amélie-Raba-Léon, Bordeaux, France. [email protected]

PMID: 11582940 DOI: 10.1016/s0929-693x(01)00564-4

Abstract

Multiple sclerosis (MS) is rare in children and occurs exceptionally before ten years. Sex ratio (girl/boy) is around 2.5 to 3, higher than in adults. Brain stem dysfunction and meningeal symptoms are more commonly first manifestations of the disease than in adults. Optic neuritis is also a frequent early manifestation. The etiology of the disease remains unclear and none of the advanced hypotheses (infectious, genetic, environmental) can by themselves explain its occurrence. There is a genetic susceptibility which is probably linked to many genes leading to a low related risk (less than two). A viral trigger mechanism in a person with a genetic predisposition is possible. New therapies result from a better understanding of the closed immune mechanisms of the disease.

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