Cancer. 2001 Sep 15;92(6):1678-83. doi: 10.1002/1097-0142(20010915)92:6+<1678::aid-cncr1496>3.0.co;2-r.
Cancer
H B Gutstein
PMID: 11598886 DOI: 10.1002/1097-0142(20010915)92:6+<1678::aid-cncr1496>3.0.co;2-r
In spite of many remarkable advances in our understanding of the mechanisms of cancer biology, very little attention has been directed toward mechanisms underlying cancer-induced symptoms. Although fatigue is a widely prevalent complication of cancer, there is a paucity of both basic and clinical research in this area. This article details our current knowledge of mechanisms causing cancer-related fatigue and briefly discusses currently available therapeutic options. A framework for addressing gaps in our knowledge and recommendations for future research directions are proposed.
Copyright 2001 American Cancer Society.