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Kogel RW, Johnson PB, Chintam R, et al. Treatment of Spasticity in Spinal Cord Injury with Dronabinol, a Tetrahydrocannabinol Derivative. Am J Ther. 1995;2(10):799-805doi: 10.1097/00045391-199510000-00012.
Kogel, R. W., Johnson, P. B., Chintam, R., Robinson, C. J., & Nemchausky, B. A. (1995). Treatment of Spasticity in Spinal Cord Injury with Dronabinol, a Tetrahydrocannabinol Derivative. American journal of therapeutics, 2(10), 799-805. https://doi.org/10.1097/00045391-199510000-00012
Kogel, Robert W., et al. "Treatment of Spasticity in Spinal Cord Injury with Dronabinol, a Tetrahydrocannabinol Derivative." American journal of therapeutics vol. 2,10 (1995): 799-805. doi: https://doi.org/10.1097/00045391-199510000-00012
Kogel RW, Johnson PB, Chintam R, Robinson CJ, Nemchausky BA. Treatment of Spasticity in Spinal Cord Injury with Dronabinol, a Tetrahydrocannabinol Derivative. Am J Ther. 1995 Oct;2(10):799-805. doi: 10.1097/00045391-199510000-00012. PMID: 11854790.
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Am J Ther. 1995 Oct;2(10):799-805. doi: 10.1097/00045391-199510000-00012.

Treatment of Spasticity in Spinal Cord Injury with Dronabinol, a Tetrahydrocannabinol Derivative.

American journal of therapeutics

Robert W. Kogel, Paul B. Johnson, Rani Chintam, Charles J. Robinson, Bernard A. Nemchausky

Affiliations

  1. Medical College of Georgia, Augusta, GA, USA.

PMID: 11854790 DOI: 10.1097/00045391-199510000-00012

Abstract

Spinal-cord-injured patients and the medical literature have increasingly reported anecdotes regarding tetrahydrocannabinol (THC)-induced spasmolysis. These reports motivated this trial of dronabinol, a THC derivative, for the treatment of spasticity in the spinal-cord-injured population. Five made quadriplegic patients were given oral dronabinol in escalating doses from 5 mg BID to 20 mg TID in addition to their current, but ineffective, spasmolytic regime. The pendulum drop test was used to quantify spasticity (stiffness) in the knees. The Weschler Memory Scale (WMS), Profile of Mood States (POMS), and personal interviews were administered by the clinical psychologist to evaluate any changes in the subjects' cognition and/or emotional states. Spasticity was markedly improved in two of the five subjects, unchanged in a third, fluctuated in a fourth and made progressively worse in a fifth. The WMS revealed improvement in memory skills of two subjects and no change in the other. Psychological interviews and the POMS indicated decreased vigor in all subject, but otherwise demonstrated highly individualized emotional changes as indicated by increases and/or decreases in the dysphoric mood scales.

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