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Clin Microbiol Infect. 1999 Apr;5(4):205-212. doi: 10.1111/j.1469-0691.1999.tb00125.x.

In vitro activity, postantibiotic effect and human monocyte activity of grepafloxacin against Legionella species.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

Jacques Dubois, Claude St-Pierre

Affiliations

  1. Centre Universitaire de Santé de l'Estrie, Sherbrooke, Québec, Canada.

PMID: 11856251 DOI: 10.1111/j.1469-0691.1999.tb00125.x

Abstract

OBJECTIVE: To determine the in vitro antimicrobial activity, postantibiotic effect (PAE) and human monocyte activity of grepafloxacin compared with sparfloxacin, ciprofloxacin, clarithromycin, erythromycin and rifampicin against 181 strains of Legionella pneumophila, nine strains of L. micdadei, 10 strains of L. dumoffii, seven strains of L. longbeachae and seven other Legionella strains. METHODS: MICs were determined by standard agar dilution using buffered yeast extract (BYE) agar. PAE and human monocyte activity were determined by standard culture techniques. RESULTS: Grepafloxacin, sparfloxacin and rifampicin were the most active agents against L. pneumophila (MIC90

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