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Yang NC, Chan SH, Chan JY. Participation of Galaninergic Neurotransmission at the Paraventricular Hypothalamic Nucleus in the Suppression of Baroreceptor Reflex Response by Locus ceruleus in the Rat. J Biomed Sci. 1997;4(2):91-97doi: 10.1007/BF02255599.
Yang, N. C., Chan, S. H., & Chan, J. Y. (1997). Participation of Galaninergic Neurotransmission at the Paraventricular Hypothalamic Nucleus in the Suppression of Baroreceptor Reflex Response by Locus ceruleus in the Rat. Journal of biomedical science, 4(2), 91-97. https://doi.org/10.1007/BF02255599
Yang, N.C., et al. "Participation of Galaninergic Neurotransmission at the Paraventricular Hypothalamic Nucleus in the Suppression of Baroreceptor Reflex Response by Locus ceruleus in the Rat." Journal of biomedical science vol. 4,2 (1997): 91-97. doi: https://doi.org/10.1007/BF02255599
Yang NC, Chan SH, Chan JY. Participation of Galaninergic Neurotransmission at the Paraventricular Hypothalamic Nucleus in the Suppression of Baroreceptor Reflex Response by Locus ceruleus in the Rat. J Biomed Sci. 1997 Mar-Jun;4(2):91-97. doi: 10.1007/BF02255599. PMID: 11725139.
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J Biomed Sci. 1997 Mar-Jun;4(2):91-97. doi: 10.1007/BF02255599.

Participation of Galaninergic Neurotransmission at the Paraventricular Hypothalamic Nucleus in the Suppression of Baroreceptor Reflex Response by Locus ceruleus in the Rat.

Journal of biomedical science

N.C. Yang, S.H.H. Chan, J.Y.H. Chan

Affiliations

  1. Department of Medical Research, Veterans General Hospital, Taipei, Taiwan.

PMID: 11725139 DOI: 10.1007/BF02255599

Abstract

We evaluated the potential participation of galanin (GAL) at the paraventricular nucleus of hypothalamus (PVN) in the suppression of baroreceptor reflex (BRR) response by locus ceruleus (LC), using adult male Sprague-Dawley rats anesthetized with pentobarbital sodium. Microinjection of GAL (100 pmol) bilaterally into the PVN significantly depressed the BRR response. This suppressive effect was appreciably antagonized when GAL (100 pmol) and GAL antiserum (1:20) were coadministered into the bilateral PVN. Whereas bilateral microinjection of GAL antiserum into the PVN by itself elicited minimal effect, it nevertheless significantly attenuated the suppressive effect of either electrical or chemical activation of LC on the BRR response. Pretreatment with the same amount of normal rabbit serum (1:20), on the other hand, was ineffective. These results suggest that a galaninergic projection from the LC to PVN may participate in the suppression of BRR response by this dorsal pontine nucleus. Copyright 1997 S. Karger AG, Basel

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