Acta Med Austriaca. 2001;28(5):117-22. doi: 10.1046/j.1563-2571.2001.01030.x.

[Pathophysiology and therapeutic aspects of left ventricular "remodeling" in the post-infarct phase].

Acta medica Austriaca

[Article in German]
J Auer, R Berent, B Eber

PMID: 11774772 DOI: 10.1046/j.1563-2571.2001.01030.x

Abstract

Left ventricular remodeling is the process by which ventricular size, shape, and function are regulated by mechanical, neurohormonal, and genetic factors. Remodeling may be physiological and adaptive during normal growth or pathological due to myocardial infarction, cardiomyopathy, hypertension, or valvular heart disease. Postinfarction remodeling has been divided into an early phase within 72 hours and a late phase beyond 72 hours. The early phase involves expansion of the infarct zone, which may result in early ventricular rupture or aneurysm formation. Late remodeling involves the left ventricle globally and is associated with time-dependent dilatation, the distortion of ventricular shape, and mural hypertrophy. Hypertrophy and collagen degradation are adaptive responses during postinfarction remodeling. Myocardial repair is triggered by cytokines released from injured myocytes. Ventricular remodeling is influenced most by infarct artery patency. Once infarct evolution has occurred, pharmacological intervention, like ACE inhibition and beta-adrenoreceptor blocking agents, may minimize infarct expansion and ventricular dilatation and improve the long-term prognosis.

MeSH terms

• Humans
• Myocardial Infarction / physiopathology
• Myocardial Infarction / therapy
• Ventricular Remodeling / physiology

Publication Types

• English Abstract
• Journal Article
• Review