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Grosbois B, Decaux O, Azais I, et al. Current treatment strategies for multiple myeloma. Eur J Intern Med. 2002;13(2):85-95doi: 10.1016/s0953-6205(01)00205-9.
Grosbois, B., Decaux, O., Azais, I., Facon, T., & Avet-Loiseau, H. (2002). Current treatment strategies for multiple myeloma. European journal of internal medicine, 13(2), 85-95. https://doi.org/10.1016/s0953-6205(01)00205-9
Grosbois, Bernard, et al. "Current treatment strategies for multiple myeloma." European journal of internal medicine vol. 13,2 (2002): 85-95. doi: https://doi.org/10.1016/s0953-6205(01)00205-9
Grosbois B, Decaux O, Azais I, Facon T, Avet-Loiseau H. Current treatment strategies for multiple myeloma. Eur J Intern Med. 2002 Mar;13(2):85-95. doi: 10.1016/s0953-6205(01)00205-9. PMID: 11893464.
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Eur J Intern Med. 2002 Mar;13(2):85-95. doi: 10.1016/s0953-6205(01)00205-9.

Current treatment strategies for multiple myeloma.

European journal of internal medicine

Bernard Grosbois, Olivier Decaux, Isabelle Azais, Thierry Facon, Hervé Avet-Loiseau

Affiliations

  1. Service de Médecine Interne, Hôpital Sud, Centre Hospitalier Universitaire de Rennes, 35056, Rennes, France

PMID: 11893464 DOI: 10.1016/s0953-6205(01)00205-9

Abstract

Until 1990, the melphalan-prednisone regimen was the standard treatment for multiple myeloma (MM). The role of alpha-interferon still remains controversial, both in induction therapy and in maintenance therapy. Over the last 10 years, there has been considerable improvement in the treatment of MM. In patients under 65 years of age, high-dose therapy with autografting has clearly demonstrated an advantage over conventional treatment. Bisphosphonates have proved very useful in reducing skeletal events. More recently, an old drug, thalidomide, has shown surprising efficacy in patients with advanced MM. Future trends include the extension of high-dose therapy to older patients and the use of immunotherapy in induction and/or maintenance therapy.

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