Display options
Cite
Odenholt I, Löwdin E, Cars O. Comparative in vitro pharmacodynamics of BO-2727, meropenem and imipenem against Gram-positive and Gram-negative bacteria. Clin Microbiol Infect. 1997;3(1):73-81doi: 10.1111/j.1469-0691.1997.tb00254.x.
Odenholt, I., Löwdin, E., & Cars, O. (1997). Comparative in vitro pharmacodynamics of BO-2727, meropenem and imipenem against Gram-positive and Gram-negative bacteria. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 3(1), 73-81. https://doi.org/10.1111/j.1469-0691.1997.tb00254.x
Odenholt, Inga, et al. "Comparative in vitro pharmacodynamics of BO-2727, meropenem and imipenem against Gram-positive and Gram-negative bacteria." Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases vol. 3,1 (1997): 73-81. doi: https://doi.org/10.1111/j.1469-0691.1997.tb00254.x
Odenholt I, Löwdin E, Cars O. Comparative in vitro pharmacodynamics of BO-2727, meropenem and imipenem against Gram-positive and Gram-negative bacteria. Clin Microbiol Infect. 1997 Feb;3(1):73-81. doi: 10.1111/j.1469-0691.1997.tb00254.x. PMID: 11864079.
Copy Download .nbib Format: NLM
Share it on

Clin Microbiol Infect. 1997 Feb;3(1):73-81. doi: 10.1111/j.1469-0691.1997.tb00254.x.

Comparative in vitro pharmacodynamics of BO-2727, meropenem and imipenem against Gram-positive and Gram-negative bacteria.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

Inga Odenholt, Elisabeth Löwdin, Otto Cars

Affiliations

  1. Antibiotic Research Unit, Department of Infectious Diseases and Clinical Microbiology, University Hospital, Uppsala, Sweden.

PMID: 11864079 DOI: 10.1111/j.1469-0691.1997.tb00254.x

Abstract

OBJECTIVE: To investigate and compare the in vitro pharmacodynamics of three carbapenems: imipenem, meropenem and BO-2727. METHODS: The following studies were performed: (1) comparative studies of the rate of killing of the three carbapenems of reference strains of Gram-positive and Gram-negative bacteria at a concentration corresponding to the 1-h serum level following 500 mg intravenously in humans; (2) comparative studies of the rate of killing of BO-2727, meropenem and imipenem at different antibiotic concentrations of reference strains of Gram-positive and Gram-negative bacteria; (3) comparative studies of the rate of killing of BO-2727, meropenem and imipenem of bacteria which are phenotypically tolerant; (4) studies of the postantibiotic effect of BO-2727 using viable counts and optical density; (5) studies of the postantibiotic sub-MIC effect (PA SME) of BO-2727 using optical density. RESULTS: No difference in killing rate was noted between the three carbapenems, and there was no concentration-dependent killing of the Gram-negative strains after 6 h. A pronounced paradoxical effect was seen against Staphylococcus aureus. All three antibiotics were able to kill phenotypically tolerant bacteria. Only very short or no postantibiotic effect of BO-2727 was found against the investigated strains. Very long PA SMEs were noted for the Gram-negative strains, although there was a pronounced variation for the different strains of Pseudomonas aeruginosa. CONCLUSION: There was no significant difference between the studied carbapenems in their pharmacodynamic properties. All three antibiotics acted similarly to other beta-lactam antibiotics.

Publication Types