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Calev A, Fink M, Petrides G, et al. Caffeine Pretreatment Enhances Clinical Efficacy and Reduces Cognitive Effects of Electroconvulsive Therapy. Convuls Ther. 1993;9(2):95-100
Calev, A., Fink, M., Petrides, G., Francis, A., & Fochtmann, L. (1993). Caffeine Pretreatment Enhances Clinical Efficacy and Reduces Cognitive Effects of Electroconvulsive Therapy. Convulsive therapy, 9(2), 95-100.
Calev, Avraham, et al. "Caffeine Pretreatment Enhances Clinical Efficacy and Reduces Cognitive Effects of Electroconvulsive Therapy." Convulsive therapy vol. 9,2 (1993): 95-100.
Calev A, Fink M, Petrides G, Francis A, Fochtmann L. Caffeine Pretreatment Enhances Clinical Efficacy and Reduces Cognitive Effects of Electroconvulsive Therapy. Convuls Ther. 1993;9(2):95-100. PMID: 11941197.
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Convuls Ther. 1993;9(2):95-100.

Caffeine Pretreatment Enhances Clinical Efficacy and Reduces Cognitive Effects of Electroconvulsive Therapy.

Convulsive therapy

Avraham Calev, Max Fink, Georgios Petrides, Andrew Francis, Laura Fochtmann

Affiliations

  1. Department of Psychiatry and Behavioral Science, State University of New York, Stony Brook, New York, USA.

PMID: 11941197

Abstract

In an open clinical trial, depressed patients received age-dosed, brief-pulse electroconvulsive therapy (ECT) either with or without 500 mg i.v. caffeine sodium benzoate before each treatment. Caffeine-pretreated patients required fewer ECT treatments, and after three to four treatments, their Hamilton Depression Scale (HDS) scores were significantly lower. At the end of the ECT course, both groups reached the same reduction in HDS scores. Of five memory tests, one showed better performance at the end of the ECT course for the caffeine-pretreated compared with the non-caffeine-pretreated patients. The results argue that caffeine-modified ECT differs from unmodified ECT in speed of response and the effects on cognitive tests.

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