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Xu MY, Lu HM, Wang SZ, et al. Effect of devazepide reversed antagonism of CCK-8 against morphine on electrical and mechanical activities of rat duodenum in vitro. World J Gastroenterol. 1998;4(6):524-526doi: 10.3748/wjg.v4.i6.524.
Xu, M. Y., Lu, H. M., Wang, S. Z., Shi, W. Y., Wang, X. C., Yang, D. X., Yang, C. X., & Yang, L. Z. (1998). Effect of devazepide reversed antagonism of CCK-8 against morphine on electrical and mechanical activities of rat duodenum in vitro. World journal of gastroenterology, 4(6), 524-526. https://doi.org/10.3748/wjg.v4.i6.524
Xu, Man-Ying, et al. "Effect of devazepide reversed antagonism of CCK-8 against morphine on electrical and mechanical activities of rat duodenum in vitro." World journal of gastroenterology vol. 4,6 (1998): 524-526. doi: https://doi.org/10.3748/wjg.v4.i6.524
Xu MY, Lu HM, Wang SZ, Shi WY, Wang XC, Yang DX, Yang CX, Yang LZ. Effect of devazepide reversed antagonism of CCK-8 against morphine on electrical and mechanical activities of rat duodenum in vitro. World J Gastroenterol. 1998 Dec;4(6):524-526. doi: 10.3748/wjg.v4.i6.524. PMID: 11819361; PMCID: PMC4723444.
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World J Gastroenterol. 1998 Dec;4(6):524-526. doi: 10.3748/wjg.v4.i6.524.

Effect of devazepide reversed antagonism of CCK-8 against morphine on electrical and mechanical activities of rat duodenum in vitro.

World journal of gastroenterology

Man-Ying Xu, Hui-Ming Lu, Shu-Zhen Wang, Wen-Yan Shi, Xin-Chun Wang, Dong-Xiao Yang, Chun-Xiao Yang, Li-Zhuang Yang

PMID: 11819361 PMCID: PMC4723444 DOI: 10.3748/wjg.v4.i6.524

Abstract

AIM:To study the antagonism of cholecystokinin octapeptide (CCK-8) against the effect of morphine and its mechanism.METHODS:The method of simultaneously recording the electrical and mechanical activities of rat duodenum in vitro was adopted.RESULTS:Acetylcholine (ACh) could increase the amplitude and the number of the spike potential (SPA and SPN of rat duodenum in vitro, followed by the increase of the duodenal contraction amplitudes (CA), showing a positive correlation. Morphine, on the contrary, inhibited the potentiation of ACh, showing a negative correlation. CCK-8 could antagonize the effects of morphine, i.e. th SPA and SPN were increased again, followed by the increase of CA. On the basis of the above, CCK-A receptor antagonist Devazepide could reverse the antagonism of CCK-8 to the effect of morphine.CONCLUSION:CCK-8 could antagonize the effect of morphine which inhibited the potentiation of ACh on the duodenal activities in vitro.Furthermore, it was inferred that the antagonistic effect of CCK-8 on morphine was mainly mediated by CCK-A receptor.

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