Display options
Cite
Liang LJ, Yin XY, Luo SM, et al. A study of the ameliorating effects of carnitine on hepatic steatosis induced by total parenteral nutrition in rats. World J Gastroenterol. 1999;5(4):312-315doi: 10.3748/wjg.v5.i4.312.
Liang, L. J., Yin, X. Y., Luo, S. M., Zheng, J. F., Lu, M. D., & Huang, J. F. (1999). A study of the ameliorating effects of carnitine on hepatic steatosis induced by total parenteral nutrition in rats. World journal of gastroenterology, 5(4), 312-315. https://doi.org/10.3748/wjg.v5.i4.312
Liang, Li-Jian, et al. "A study of the ameliorating effects of carnitine on hepatic steatosis induced by total parenteral nutrition in rats." World journal of gastroenterology vol. 5,4 (1999): 312-315. doi: https://doi.org/10.3748/wjg.v5.i4.312
Liang LJ, Yin XY, Luo SM, Zheng JF, Lu MD, Huang JF. A study of the ameliorating effects of carnitine on hepatic steatosis induced by total parenteral nutrition in rats. World J Gastroenterol. 1999 Aug;5(4):312-315. doi: 10.3748/wjg.v5.i4.312. PMID: 11819455; PMCID: PMC4695542.
Copy Download .nbib Format: NLM
Share it on

World J Gastroenterol. 1999 Aug;5(4):312-315. doi: 10.3748/wjg.v5.i4.312.

A study of the ameliorating effects of carnitine on hepatic steatosis induced by total parenteral nutrition in rats.

World journal of gastroenterology

Li-Jian Liang, Xiao-Yu Yin, Shi-Min Luo, Jin-Fang Zheng, Ming-De Lu, Jie-Fu Huang

PMID: 11819455 PMCID: PMC4695542 DOI: 10.3748/wjg.v5.i4.312

Abstract

AIM:To investigate the effects of carnitine on ameliorating hepatic steatosis induced by total parenteral nutrition (TPN) in animal model.METHODS: Eighteen normal Wistar rats and 19 cirrhotic Wistar rats induced by carbon tetrachloride were randomly divided into three groups, i.e., free access to food and drink (group A), TPN (group B) and TPN+carnitine (group C) for one week, respectively. Hepatic function, histology and its fat content were determined on the 7th day.RESULTS: Hepatic triglyceride (TG) and cholesterol (CHO) contents were significantly higher in groups B and C than in group A,and significantly lower in group C than in group B in both normal and cirrhotic rats (all P < 0.05). Histopathological examinations revealed that hepatic steatosis was more severe in group B than in group C in both normal and cirrhotic rats.CONCLUSION:Carnitine can ameliorate hepatic steatosis associated with TPN in both non-cirrhotic and cirrhotic rats.

References

  1. Am J Clin Nutr. 1986 Jan;43(1):85-91 - PubMed
  2. J Pediatr. 1992 May;120(5):759-62 - PubMed
  3. JPEN J Parenter Enteral Nutr. 1992 May-Jun;16(3):279-83 - PubMed
  4. J Pediatr. 1995 Feb;126(2):287-92 - PubMed
  5. J Nutr. 1979 May;109(5):904-15 - PubMed
  6. J Clin Invest. 1977 Sep;60(3):716-23 - PubMed
  7. Hepatology. 1988 Jan-Feb;8(1):61-4 - PubMed
  8. Am J Clin Nutr. 1982 Oct;36(4):569-72 - PubMed

Publication Types