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Bian JC, Shen FM, Shen L, et al. Susceptibility to hepatocellular carcinoma associated with null genotypes of GSTM1 and GSTT1. World J Gastroenterol. 2000;6(2):228-230doi: 10.3748/wjg.v6.i2.228.
Bian, J. C., Shen, F. M., Shen, L., Wang, T. R., Wang, X. H., Chen, G. C., & Wang, J. B. (2000). Susceptibility to hepatocellular carcinoma associated with null genotypes of GSTM1 and GSTT1. World journal of gastroenterology, 6(2), 228-230. https://doi.org/10.3748/wjg.v6.i2.228
Bian, Jian-Chao, et al. "Susceptibility to hepatocellular carcinoma associated with null genotypes of GSTM1 and GSTT1." World journal of gastroenterology vol. 6,2 (2000): 228-230. doi: https://doi.org/10.3748/wjg.v6.i2.228
Bian JC, Shen FM, Shen L, Wang TR, Wang XH, Chen GC, Wang JB. Susceptibility to hepatocellular carcinoma associated with null genotypes of GSTM1 and GSTT1. World J Gastroenterol. 2000 Apr;6(2):228-230. doi: 10.3748/wjg.v6.i2.228. PMID: 11819562; PMCID: PMC4723490.
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World J Gastroenterol. 2000 Apr;6(2):228-230. doi: 10.3748/wjg.v6.i2.228.

Susceptibility to hepatocellular carcinoma associated with null genotypes of GSTM1 and GSTT1.

World journal of gastroenterology

Jian-Chao Bian, Fu-Ming Shen, Li Shen, Tian-Ru Wang, Xiao-Hong Wang, Gong-Chao Chen, Jin-Bing Wang

PMID: 11819562 PMCID: PMC4723490 DOI: 10.3748/wjg.v6.i2.228

Abstract

AIM:In order to study the association between the null genotypes of GSTM1 and GSTT1 and the genetic susceptibility to hepatocellular carcinoma (HCC).METHODS:The genotypes of GSTM1 and GSTT1 of 63 cases of HCC and 88 controls were detected with the multiple PCR technique.RESULTS:The frequency of GSTM1 null genotype was 57.1% among the cases, and 42.0% among the controls, the difference being statistically significant (X(2) = 3.35, P = 0.067), but X(2) value approaching the significance level. The odds ratio was 1.84 (95% CI = 0.91-3.37). The frequency of GSTT1 non-null genotype was 87.3% among the cases and 62.5% among the controls, the difference being statistically significant (X(2) = 11.42, P = 0.0007274). The odds ratio was 4.13 (95% CI = 1.64-10.70).According to the cross analysis, the GSTT1 non null genotype was more closely associated with HCC than GSTM1 null genotype, and these two factors play an approximate additive interaction in the occurrence of HCC.CONCLUSION:The persons with GSTM1 null genotype and GSTT1 non-null genotype have the increased risk to HCC.

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