Display options
Cite
Tanaka K, Teraoka H, Tamaki M. Peptidyl puromycin synthesis; effect of several antibiotics which act on 50 S ribosomal subunits. FEBS Lett. 1971;13(1):65-67doi: 10.1016/0014-5793(71)80666-x.
Tanaka, K., Teraoka, H., & Tamaki, M. (1971). Peptidyl puromycin synthesis; effect of several antibiotics which act on 50 S ribosomal subunits. FEBS letters, 13(1), 65-67. https://doi.org/10.1016/0014-5793(71)80666-x
Tanaka, K, et al. "Peptidyl puromycin synthesis; effect of several antibiotics which act on 50 S ribosomal subunits." FEBS letters vol. 13,1 (1971): 65-67. doi: https://doi.org/10.1016/0014-5793(71)80666-x
Tanaka K, Teraoka H, Tamaki M. Peptidyl puromycin synthesis; effect of several antibiotics which act on 50 S ribosomal subunits. FEBS Lett. 1971 Feb 12;13(1):65-67. doi: 10.1016/0014-5793(71)80666-x. PMID: 11945634.
Copy Download .nbib Format: NLM
Share it on

FEBS Lett. 1971 Feb 12;13(1):65-67. doi: 10.1016/0014-5793(71)80666-x.

Peptidyl puromycin synthesis; effect of several antibiotics which act on 50 S ribosomal subunits.

FEBS letters

K Tanaka, H Teraoka, M Tamaki

Affiliations

  1. Shionogi Research Laboratory, Shionogi and Co., Ltd. Fukushima-ku, Osaka, Japan

PMID: 11945634 DOI: 10.1016/0014-5793(71)80666-x

Abstract

The effects of several antibiotics which are know to bind with 50 S ribosomal subunits, on the formation of several di- and tri-peptidyl puromycins have been examined. Tylosin and spiramycin inhibited the formation of phenylalanyl-(14)C-phenylalanyl-puromycin, glycyl-(14)C-phenyllalanyl-puromycin, leucyl-(14)C-phenylalanyl-puromycin, N(epsilon)-carbobenzoxylysyl-(14)C-phenylalanyl-puromycin, and valyl-glycyl-(14)C-phenylalanyl-puromycin as well as N-acetyl-(14)C-phenylalanyl-puromycin. Of these compounds, erythromycin and oleandomycin selectively inhibited the formation of phenylalanyl-(14)C-phenylalanyl-puromycin. Although chloramphenicol and lincomycin inhibited the formation of most of these peptidyl puromycins, the formation of phenylalanyl-(14)C-phenylalanyl-puromycin and leucyl-(14)C-phenylalanyl-puromycin was found to be resistant to these antibiotics. So far, no significant effect of siomycin has been observed on pepetidyl puromycin formation in the absence of G factor.

Publication Types