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Samonina G, Ashmarin I, Lyapina L. Glyproline peptide family: review on bioactivity and possible origins. Pathophysiology. 2002;8(4):229-234doi: 10.1016/s0928-4680(02)00018-4.
Samonina, G., Ashmarin, I., & Lyapina, L. (2002). Glyproline peptide family: review on bioactivity and possible origins. Pathophysiology : the official journal of the International Society for Pathophysiology, 8(4), 229-234. https://doi.org/10.1016/s0928-4680(02)00018-4
Samonina, G, et al. "Glyproline peptide family: review on bioactivity and possible origins." Pathophysiology : the official journal of the International Society for Pathophysiology vol. 8,4 (2002): 229-234. doi: https://doi.org/10.1016/s0928-4680(02)00018-4
Samonina G, Ashmarin I, Lyapina L. Glyproline peptide family: review on bioactivity and possible origins. Pathophysiology. 2002 Aug;8(4):229-234. doi: 10.1016/s0928-4680(02)00018-4. PMID: 12100966.
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Pathophysiology. 2002 Aug;8(4):229-234. doi: 10.1016/s0928-4680(02)00018-4.

Glyproline peptide family: review on bioactivity and possible origins.

Pathophysiology : the official journal of the International Society for Pathophysiology

G Samonina, I Ashmarin, L Lyapina

Affiliations

  1. Department of Human and Animal Physiology, School of Biology, Moscow State Lomonosov University, Vorobjevy Gory 1, Building 12, 119899, Moscow, Russia

PMID: 12100966 DOI: 10.1016/s0928-4680(02)00018-4

Abstract

Glyproline peptide family includes the simplest proline-containing linear peptides PG, GP, PGP, respective peptides with hydroxylated proline residues and (with some restriction) cyclic PG. Having close structural resemblance they display many similar bioactivities. The suppression of some reactions of blood coagulation and platelet aggregation and protection of gastric mucosa against various ulcerogenic factors are the most important glyproline effects. Glyprolines have two common putative sources: (1) collagen and elastin synthesis and catabolism, and (2) penetration of proline-containing di- and tripeptides from food protein hydrolysate from the intestine into bloodstream. Possible physiological and biochemical mechanisms of glyproline bioactivities are under discussion.

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