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Henson KL, Alleman AR, Kelley LC, et al. Immunohistochemical characterization of estrogen and progesterone receptors in lymphoma of horses. Vet Clin Pathol. 2000;29(2):40-46doi: 10.1111/j.1939-165x.2000.tb00396.x.
Henson, K. L., Alleman, A. R., Kelley, L. C., & Mahaffey, E. A. (2000). Immunohistochemical characterization of estrogen and progesterone receptors in lymphoma of horses. Veterinary clinical pathology, 29(2), 40-46. https://doi.org/10.1111/j.1939-165x.2000.tb00396.x
Henson, Kristin L., et al. "Immunohistochemical characterization of estrogen and progesterone receptors in lymphoma of horses." Veterinary clinical pathology vol. 29,2 (2000): 40-46. doi: https://doi.org/10.1111/j.1939-165x.2000.tb00396.x
Henson KL, Alleman AR, Kelley LC, Mahaffey EA. Immunohistochemical characterization of estrogen and progesterone receptors in lymphoma of horses. Vet Clin Pathol. 2000;29(2):40-46. doi: 10.1111/j.1939-165x.2000.tb00396.x. PMID: 12070809.
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Vet Clin Pathol. 2000;29(2):40-46. doi: 10.1111/j.1939-165x.2000.tb00396.x.

Immunohistochemical characterization of estrogen and progesterone receptors in lymphoma of horses.

Veterinary clinical pathology

Kristin L. Henson, A. Rick Alleman, Lynda C. Kelley, Edward A. Mahaffey

Affiliations

  1. Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA. [email protected]

PMID: 12070809 DOI: 10.1111/j.1939-165x.2000.tb00396.x

Abstract

Immunohistochemical techniques were used to examine 29 cases of equine lymphoma for estrogen receptor (ER) and progesterone receptor (PR) expression. The lymphomas examined included T-cell-rich large B-cell lymphomas, B-cell neoplasms, and T-cell lymphomas. The individual cases were also classified according to the anatomic location of the tumors. One normal equine lymph node was also examined for ER and PR expression. All of the cases of equine lymphoma and the normal lymph node were negative for Er. A total of 16/29 (55%) PR-positive lymphomas were identified. Seven of the 12 (58%) T-cell-rich large B-cell lymphomas were positive, 7/11 (64%) B-cell tumors were positive, and 2/6 (33%) T-cell neoplasms were positive. Anatomically, 6/9 (66%) subcutaneous lymphomas were PR positive, 3/5 (60%) intrathoracic lymphomas were positive, 1/4 (25%) intra-abdominal lymphomas were positive, 2/5 (40%) intra-abdominal/intrathoracic lymphomas were positive, 1/2 (50%) upper airway lymphomas were positive, and 3/3 (100%) splenic lymphomas were positive. One case involving abdominal and thoracic tumors and leukemia was negative for PR expression. The normal lymph node contained a low percentage (1.9%) of PR-positive lymphocytes. The presence of PR in neoplastic equine lymphoid tissue indicates that these tumors may be responsive to serum progesterone. Also, identification of PR-positive cells in the normal lymph node suggests that PR may be constitutively expressed in normal equine lymphocytes. Further studies are needed to quantify PR levels in normal and malignant equine lymphoid tissue and to determine the usefulness of either progestin or antiprogestin drugs in the management of equine lymphoma.

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