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Blum T, Ermert J, Coenen HH. No-carrier-added (n.c.a.) synthesis of asymmetric [73,75Se]selenoethers with isonitriles. Appl Radiat Isot. 2002;57(1):51-6doi: 10.1016/s0969-8043(02)00071-4.
Blum, T., Ermert, J., & Coenen, H. H. (2002). No-carrier-added (n.c.a.) synthesis of asymmetric [73,75Se]selenoethers with isonitriles. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 57(1), 51-6. https://doi.org/10.1016/s0969-8043(02)00071-4
Blum, T, et al. "No-carrier-added (n.c.a.) synthesis of asymmetric [73,75Se]selenoethers with isonitriles." Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine vol. 57,1 (2002): 51-6. doi: https://doi.org/10.1016/s0969-8043(02)00071-4
Blum T, Ermert J, Coenen HH. No-carrier-added (n.c.a.) synthesis of asymmetric [73,75Se]selenoethers with isonitriles. Appl Radiat Isot. 2002 Jul;57(1):51-6. doi: 10.1016/s0969-8043(02)00071-4. PMID: 12137026.
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Appl Radiat Isot. 2002 Jul;57(1):51-6. doi: 10.1016/s0969-8043(02)00071-4.

No-carrier-added (n.c.a.) synthesis of asymmetric [73,75Se]selenoethers with isonitriles.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

T Blum, J Ermert, H H Coenen

Affiliations

  1. Institut für Nuklearchemie, Forschungszentrum Jülich GmbH, Germany.

PMID: 12137026 DOI: 10.1016/s0969-8043(02)00071-4

Abstract

A new synthetic pathway for the preparation of no-carrier-added (n.c.a.) [73.75Se]selenoethers was investigated in order to enlarge the scope of available radioselenated compounds. Starting from n.c.a. 73,75Se(0), an isonitrile and an amine, the preparation of appropriate disubstituted radioselenoureas via homogenous and polymer-supported reactions was examined. Alkylation of these intermediates yielded the corresponding [73-75S]selenouronium salts. Hydrolysis under basic conditions provided the [73,75Se]alkylselenolates and a subsequent alkylation yielded various asymmetric [73-75Se]selenoethers with radiochemical yields of 13-56% within a reaction time of 130min in the homogenous phase and 35 min using the polymer-supported synthesis.

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