Display options
Cite
Dehpour AR, Samini M, Rastegar H, et al. Effect of NMDA receptor antagonist on naloxone-precipitated withdrawal signs in cholestatic mice. Hum Psychopharmacol. 2000;15(3):213-218doi: 10.1002/(SICI)1099-1077(200004)15:3<213::AID-HUP159>3.0.CO;2-Z.
Dehpour, A. R., Samini, M., Rastegar, H., Ardeshiri, A. J., Roushanzamir, F., Jorjani, M., & Ahmadiani, A. (2000). Effect of NMDA receptor antagonist on naloxone-precipitated withdrawal signs in cholestatic mice. Human psychopharmacology, 15(3), 213-218. https://doi.org/10.1002/(SICI)1099-1077(200004)15:3<213::AID-HUP159>3.0.CO;2-Z
Dehpour, Ahmad Reza, et al. "Effect of NMDA receptor antagonist on naloxone-precipitated withdrawal signs in cholestatic mice." Human psychopharmacology vol. 15,3 (2000): 213-218. doi: https://doi.org/10.1002/(SICI)1099-1077(200004)15:3<213::AID-HUP159>3.0.CO;2-Z
Dehpour AR, Samini M, Rastegar H, Ardeshiri AJ, Roushanzamir F, Jorjani M, Ahmadiani A. Effect of NMDA receptor antagonist on naloxone-precipitated withdrawal signs in cholestatic mice. Hum Psychopharmacol. 2000 Apr;15(3):213-218. doi: 10.1002/(SICI)1099-1077(200004)15:3<213::AID-HUP159>3.0.CO;2-Z. PMID: 12404334.
Copy Download .nbib Format: NLM
Share it on

Hum Psychopharmacol. 2000 Apr;15(3):213-218. doi: 10.1002/(SICI)1099-1077(200004)15:3<213::AID-HUP159>3.0.CO;2-Z.

Effect of NMDA receptor antagonist on naloxone-precipitated withdrawal signs in cholestatic mice.

Human psychopharmacology

Ahmad Reza Dehpour, Morteza Samini, Hossein Rastegar, Abazar Jamshidi Ardeshiri, Farshad Roushanzamir, Masoumeh Jorjani, Abolhassan Ahmadiani

Affiliations

  1. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

PMID: 12404334 DOI: 10.1002/(SICI)1099-1077(200004)15:3<213::AID-HUP159>3.0.CO;2-Z

Abstract

The ability of NMDA antagonist MK-801 to block the expression of opioid-like withdrawal signs was examined in bile duct-ligated mice and the signs were compared with sham operated and unoperated animals. Administration of MK-801 (0/1 mg/kg), 10 min prior to naloxone challenge, significantly reduced the investigated withdrawal signs (jumping, diarrhoea, grooming and climbing) in bile duct-ligated animals. Chronic administration (five consecutive days) of MK-801 (0/1 mg/kg) also decreased all the withdrawal signs in the experimental animals. In an independent series of experiments, the effect of acute and chronic administration of MK-801 on tail-flick latency was investigated in bile duct-ligated animals. Pretreatment with the drug significantly decreased the antinociception induced by bile duct ligation in the mice. The results of this study support evidence for the involvement of the NMDA receptor in yopioidergic-dependent manifestations in a model of obstructive cholestasis. Copyright 2000 John Wiley & Sons, Ltd.

Publication Types