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Toren P, Eldar S, Laor N, et al. Fluvoxamine is ineffective in the treatment of enuresis in children and adolescents: an open-label pilot study. Hum Psychopharmacol. 2001;16(4):327-332doi: 10.1002/hup.301.
Toren, P., Eldar, S., Laor, N., Wolmer, L., Samuel, E., & Weizman, R. (2001). Fluvoxamine is ineffective in the treatment of enuresis in children and adolescents: an open-label pilot study. Human psychopharmacology, 16(4), 327-332. https://doi.org/10.1002/hup.301
Toren, Paz, et al. "Fluvoxamine is ineffective in the treatment of enuresis in children and adolescents: an open-label pilot study." Human psychopharmacology vol. 16,4 (2001): 327-332. doi: https://doi.org/10.1002/hup.301
Toren P, Eldar S, Laor N, Wolmer L, Samuel E, Weizman R. Fluvoxamine is ineffective in the treatment of enuresis in children and adolescents: an open-label pilot study. Hum Psychopharmacol. 2001 Jun;16(4):327-332. doi: 10.1002/hup.301. PMID: 12404568.
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Hum Psychopharmacol. 2001 Jun;16(4):327-332. doi: 10.1002/hup.301.

Fluvoxamine is ineffective in the treatment of enuresis in children and adolescents: an open-label pilot study.

Human psychopharmacology

Paz Toren, Sofia Eldar, Nathaniel Laor, Leo Wolmer, Eliahu Samuel, Ronit Weizman

Affiliations

  1. Tel Aviv Community Mental Health Center and the Sackler School of Medicine Tel-Aviv University, Israel.

PMID: 12404568 DOI: 10.1002/hup.301

Abstract

Tricyclic antidepressants possess established antienuretic properties. The selective serotonin reuptake inhibitors (SSRIs) have similar antidepressant properties to the tricyclic antidepressants and a safer side effect profile. The aim of the present study was to evaluate the antienuretic efficacy of one SSRI, fluvoxamine. Nine children aged 9 to 14 years with primary enuresis which was resistant to behavioral therapy participated in the study. All received fluvoxamine, 75-100 mg per day. In four, the enuresis was the only focus of clinical attention, and five received fluvoxamine for other primary indications. Enuresis was monitored daily, and mean voiding frequency was compared between three phases: baseline, on treatment and off treatment. Fluvoxamine had no statistically significant effect on enuresis. Fluvoxamine does not seem to possess significant antienuretic properties. We suggest that the combination of serotonergic with anticholinergic activity is a major factor in the antienuretic activity. In the treatment of children or adolescents with obsessive-compulsive disorder and comorbid enuresis, clomipramine may be preferred over SSRIs. Copyright 2001 John Wiley & Sons, Ltd.

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