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Zhang X, Tang YH, Feng YM, et al. Growth Promoting Activity of Chimeric Molecules of "Insulin-Insulin-like Growth Factor-I" . Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 1996;28(4):434-437
Zhang, X., Tang, Y. H., Feng, Y. M., & Jing, N. H. (1996). Growth Promoting Activity of Chimeric Molecules of "Insulin-Insulin-like Growth Factor-I" . Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica, 28(4), 434-437.
Zhang, Xin, et al. "Growth Promoting Activity of Chimeric Molecules of "Insulin-Insulin-like Growth Factor-I" ." Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica vol. 28,4 (1996): 434-437.
Zhang X, Tang YH, Feng YM, Jing NH. Growth Promoting Activity of Chimeric Molecules of "Insulin-Insulin-like Growth Factor-I" . Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 1996;28(4):434-437. PMID: 12232638.
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Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 1996;28(4):434-437.

Growth Promoting Activity of Chimeric Molecules of "Insulin-Insulin-like Growth Factor-I" .

Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica

Xin Zhang, Yue-Hua Tang, You-Min Feng, Nai-He Jing

Affiliations

  1. National Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry, Academia Sinica, Shanghai 200031, China.

PMID: 12232638

Abstract

The chimeric molecules of "Insulin-Insulin-like Growth Factor-I", Ins/IGFI(8) and Ins/IGF-I(11) were obtained by means of enzymatic semisynthesis. The growth promoting activity of these chimeric molecules were evaluated with a mouse mammary tumor derived cell line, GR2H6, and compared with that of IGF-I, insulin and desoctapeptide insulin (DOI). Both compounds have lower activities than IGF-I and effects similar to insulin, but are more potent mitogens than DOI. These results indicate that the C-terminus of insulin B-chain is importantly involved in its growth promoting activities.

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