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Ungheri D, Pisani C, Sanson G, et al. Protective effect of n-acetylcysteine in a model of influenza infection in mice. Int J Immunopathol Pharmacol. 2000;13(3):123-128
Ungheri, D., Pisani, C., Sanson, G., Bertani, A., Schioppacassi, G., Delgado, R., Sironi, M., & Ghezzi, P. (2000). Protective effect of n-acetylcysteine in a model of influenza infection in mice. International journal of immunopathology and pharmacology, 13(3), 123-128.
Ungheri, D, et al. "Protective effect of n-acetylcysteine in a model of influenza infection in mice." International journal of immunopathology and pharmacology vol. 13,3 (2000): 123-128.
Ungheri D, Pisani C, Sanson G, Bertani A, Schioppacassi G, Delgado R, Sironi M, Ghezzi P. Protective effect of n-acetylcysteine in a model of influenza infection in mice. Int J Immunopathol Pharmacol. 2000 Sep-Dec;13(3):123-128. PMID: 12657201.
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Int J Immunopathol Pharmacol. 2000 Sep-Dec;13(3):123-128.

Protective effect of n-acetylcysteine in a model of influenza infection in mice.

International journal of immunopathology and pharmacology

D Ungheri, C Pisani, G Sanson, A Bertani, G Schioppacassi, R Delgado, M Sironi, P Ghezzi

Affiliations

  1. Zambon Research, 20092 Bresso, Milan, Italy.

PMID: 12657201

Abstract

Reactive oxygen intermediates (ROI) and cytokines, particularly tumor necrosis factor (TNF) have been implicated in the pathogenesis of influenza. Using a murine model of influenza, we have studied the levels of TNF, interleukin 6 (IL-6) and of superoxide-generating xanthine oxidase (XO). Mice infected intranasally with influenza virus APR/8 had high levels of XO, TNF and IL-6 in the broncoalveolar lavage, as early as 3 d after infection. XO was elevated also in serum and lung tissue. Administration of the antioxidant N-acetylcysteine (NAC,1 g/kg per day, orally) significantly decreased the mortality in infected mice, indicating a role for RO1 in the lethality associated with influenza infection.

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