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Wu RJ, Zhou FZ. [Endometrial insulin-like growth factor II and type I receptor in unexplained infertility and its steroid regulation]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2002;31(3):163-166doi: 10.3785/j.issn.1008-9292.2002.03.007.
Wu, R. J., & Zhou, F. Z. (2002). [Endometrial insulin-like growth factor II and type I receptor in unexplained infertility and its steroid regulation]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 31(3), 163-166. https://doi.org/10.3785/j.issn.1008-9292.2002.03.007
Wu, Rui-Jin, and Zhou, Fu-Zhen. "[Endometrial insulin-like growth factor II and type I receptor in unexplained infertility and its steroid regulation]." Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences vol. 31,3 (2002): 163-166. doi: https://doi.org/10.3785/j.issn.1008-9292.2002.03.007
Wu RJ, Zhou FZ. [Endometrial insulin-like growth factor II and type I receptor in unexplained infertility and its steroid regulation]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2002 Jun;31(3):163-166. doi: 10.3785/j.issn.1008-9292.2002.03.007. Chinese. PMID: 12596304.
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Zhejiang Da Xue Xue Bao Yi Xue Ban. 2002 Jun;31(3):163-166. doi: 10.3785/j.issn.1008-9292.2002.03.007.

[Endometrial insulin-like growth factor II and type I receptor in unexplained infertility and its steroid regulation].

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences

[Article in Chinese]
Rui-Jin Wu, Fu-Zhen Zhou

Affiliations

  1. The Affiliated Obstetrics and Gynecology Hospital, College of Medical Sciences, Zhejiang University, Hangzhou 310006, China.

PMID: 12596304 DOI: 10.3785/j.issn.1008-9292.2002.03.007

Abstract

OBJECTIVE: To investigate the endometrial expression of insulin-like growth factor II(IGF-II) and type I receptor(IGF-1R) in unexplained infertility. METHODS: Reverse transcription-polymerase chain reaction (RT-PCR) was used to detect and quantify endometrial IGF-II and IGF-I R mRNA experession in the mid-luteal phase. Serum concentrations of estradiol(E(2)) and progesterone (P) were measured by radioimmunoassays. Thirty-four women with unexplained infertility were included in the study group. Twenty-one women with normal fertility were selected as the control group. RESULTS: Endometrial IGF-II and IGF-I R mRNA experession during the midluteal phase were significantly lower in the study group than in the control group (0.662 +/- 0.371 compared with 0.961+/- 0.389, P< 0.05; 0.582 +/- 0.257 compared with 0.829 +/-0.341, P< 0.05 respectively). The average serum P level in the study group was significantly lower than in the control group (23.782 +/-15.459 compared with 43.142 +/- 16.549nmol/L, P< 0.005). IGF-II mRNA expression correlated positively with IGF-I R mRNA expression in the two groups. Serum P level correlated positively with IGF-II and IGF-I R mRNA expression in the two groups. CONCLUSION: IGF-II and IGF-I R may play an important role in the implantation process. Their decreased expression relating to decreased P level may be important in unexplained infertility.

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