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Gao JQ, Wang H, Liang WQ, et al. [Transdermal delivery of diclofenac sodium gel after iontophoresis]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2002;31(6):437-439doi: 10.3785/j.issn.1008-9292.2002.06.009.
Gao, J. Q., Wang, H., Liang, W. Q., & Chen, M. X. (2002). [Transdermal delivery of diclofenac sodium gel after iontophoresis]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 31(6), 437-439. https://doi.org/10.3785/j.issn.1008-9292.2002.06.009
Gao, Jian-Qing, et al. "[Transdermal delivery of diclofenac sodium gel after iontophoresis]." Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences vol. 31,6 (2002): 437-439. doi: https://doi.org/10.3785/j.issn.1008-9292.2002.06.009
Gao JQ, Wang H, Liang WQ, Chen MX. [Transdermal delivery of diclofenac sodium gel after iontophoresis]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2002 Aug;31(6):437-439. doi: 10.3785/j.issn.1008-9292.2002.06.009. Chinese. PMID: 12601860.
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Zhejiang Da Xue Xue Bao Yi Xue Ban. 2002 Aug;31(6):437-439. doi: 10.3785/j.issn.1008-9292.2002.06.009.

[Transdermal delivery of diclofenac sodium gel after iontophoresis].

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences

[Article in Chinese]
Jian-Qing Gao, Hua Wang, Wen-Quan Liang, Ming-Xia Chen

Affiliations

  1. College of Pharmacy, Zhejiang University, Hangzhou 310031, China.

PMID: 12601860 DOI: 10.3785/j.issn.1008-9292.2002.06.009

Abstract

OBJECTIVE: To observe the in vivo effect of combined iontophoresis and laurocapram pretreatment on transdermal delivery of diclofenac sodium gel. METHODS: Diclofenac sodium gel was prepared using polyvinyl alcohol, carboxymethylcellulose sodium and hydroxypropylmethyl cellulose. The diclofenac blood level in rabbits was measured in four groups: passive diffusion, laurocapram pretreatment, iontophoresis (current density controlled at 0.3 mA/cm(2)) and combined laurocapram pretreatment and iontophoresis. Rabbit stratum corneum of each of the four groups was examined using a scanning electron microscope. RESULTS: Diclofenac blood concentration in the passive diffusion group was undetectable. The diclofenac blood concentration area under the curve compared with time was 8.4 &mgr;l ml(-1) h(-1) in the laurocapram pretreatment group, 2.7 &mgr;l ml(-1) h(-1) in the iontophoresis group and 15.4 &mgr;l ml(-1) h(-1) in the combination group. There was no detectable damage observed by scanning electron microscopyto the stratum corneum after iontophoresis or laurocapram pretreatment. CONCLUSION: The combination of iontophoresis and laurocapram pretreatment appears to enhance transdermal delivery of diclofenac sodium gel wi thout significant skin damage.

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