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Chem Commun (Camb). 2003 Mar 21;(6):766-7.

Regioselective N-substitution of cyclen with two different alkyl groups: synthesis of all possible isomers.

Chemical communications (Cambridge, England)

Jeongsoo Yoo, David E Reichert, Michael J Welch

Affiliations

  1. Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St. Louis, MO 63110, USA.

PMID: 12703813

Abstract

All possible configurations of two different groups on the four nitrogen atoms of cyclen were achieved using four differently protected cyclen intermediates including the novel mono-protected cyclen compound, mono-N-Cbz-cyclen.

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