Curr Treat Options Gastroenterol. 2003 Feb;6(1):13-16. doi: 10.1007/s11938-003-0028-3.
Current treatment options in gastroenterology
Mark C. Flemmer, Ronald W. Flenner
PMID: 12521567 DOI: 10.1007/s11938-003-0028-3
Therapy for Whipple's disease should be continued for a minimum of 1 year, and the regimen should include an agent or agents that achieve acceptable concentrations in the central nervous system, given the likelihood of recurrence at this site. Clinical follow-up of proven cases of Whipple's disease should be conducted for a minimum of 10 years after discontinuation of therapy, given the potential for late relapses. Polymerase chain reaction analysis is preferred rather than endoscopy when evaluating for disease recurrence.