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Bhal PS, Pugh ND, Gregory L, et al. The potential effect of controlled ovarian hyperstimulation on follicular vascular perfusion: a study applying power Doppler ultrasonography within a treatment programme using donor sperm. J Obstet Gynaecol. 2001;21(5):507-12doi: 10.1080/01443610120072108.
Bhal, P. S., Pugh, N. D., Gregory, L., Goacher, L., Wells, C., & Shaw, R. W. (2001). The potential effect of controlled ovarian hyperstimulation on follicular vascular perfusion: a study applying power Doppler ultrasonography within a treatment programme using donor sperm. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 21(5), 507-12. https://doi.org/10.1080/01443610120072108
Bhal, P S, et al. "The potential effect of controlled ovarian hyperstimulation on follicular vascular perfusion: a study applying power Doppler ultrasonography within a treatment programme using donor sperm." Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology vol. 21,5 (2001): 507-12. doi: https://doi.org/10.1080/01443610120072108
Bhal PS, Pugh ND, Gregory L, Goacher L, Wells C, Shaw RW. The potential effect of controlled ovarian hyperstimulation on follicular vascular perfusion: a study applying power Doppler ultrasonography within a treatment programme using donor sperm. J Obstet Gynaecol. 2001 Sep;21(5):507-12. doi: 10.1080/01443610120072108. PMID: 12521809.
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J Obstet Gynaecol. 2001 Sep;21(5):507-12. doi: 10.1080/01443610120072108.

The potential effect of controlled ovarian hyperstimulation on follicular vascular perfusion: a study applying power Doppler ultrasonography within a treatment programme using donor sperm.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology

P S Bhal, N D Pugh, L Gregory, L Goacher, C Wells, R W Shaw

Affiliations

  1. Department of Obstetrics and Gynaecology, University Hospital of Wales, Heath Park, Cardiff, Wales, UK. [email protected]

PMID: 12521809 DOI: 10.1080/01443610120072108

Abstract

This was a prospective observational study to evaluate the effect of controlled ovarian hyperstimulation on follicular vascularity. A subjective grading system was applied to assess vascularity using transvaginal power Doppler ultrasonography on the day of insemination (32-36 hours post-HCG administration) in donor treatment cycles undergoing either controlled ovarian hyperstimulation (COH group) with gonadotrophin and intrauterine insemination or intracervical insemination with/without clomiphene stimulation (non-COH group). The incidence of follicles (81% vs. 53%; P < 0.05) as well as cycles (63% vs. 49%; P < 0.05) with uniformly high grade vascularity was significantly higher in treatments that had controlled ovarian hyperstimulation compared with unstimulated or clomiphene induced donor cycles. Pregnancy rates were higher and early pregnancy loss rates lower, in cycles with uniformly high grade follicular vascularity in both treatment groups compared with other vascularity grades. Using multiple logistic regression analysis, the only independent variable that was significantly related to pregnancy rates in this treatment programme was follicular vascularity. Controlled ovarian hyperstimulation appears to have an effect on follicular vascularity and this may contribute to improved outcome in donor insemination treatment programmes.

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