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Katritzky AR, Abdel-Fattah AA, Wang M. Expedient acylations of primary and secondary alkyl cyanides to alpha-substituted beta-ketonitriles. J Org Chem. 2003;68(12):4932-4doi: 10.1021/jo026796x.
Katritzky, A. R., Abdel-Fattah, A. A., & Wang, M. (2003). Expedient acylations of primary and secondary alkyl cyanides to alpha-substituted beta-ketonitriles. The Journal of organic chemistry, 68(12), 4932-4. https://doi.org/10.1021/jo026796x
Katritzky, Alan R, et al. "Expedient acylations of primary and secondary alkyl cyanides to alpha-substituted beta-ketonitriles." The Journal of organic chemistry vol. 68,12 (2003): 4932-4. doi: https://doi.org/10.1021/jo026796x
Katritzky AR, Abdel-Fattah AA, Wang M. Expedient acylations of primary and secondary alkyl cyanides to alpha-substituted beta-ketonitriles. J Org Chem. 2003 Jun 13;68(12):4932-4. doi: 10.1021/jo026796x. PMID: 12790602.
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J Org Chem. 2003 Jun 13;68(12):4932-4. doi: 10.1021/jo026796x.

Expedient acylations of primary and secondary alkyl cyanides to alpha-substituted beta-ketonitriles.

The Journal of organic chemistry

Alan R Katritzky, Ashraf A A Abdel-Fattah, Mingyi Wang

Affiliations

  1. Department of Chemistry, Center for Heterocyclic Compounds, University of Florida, Gainesville, FL 32611-7200, USA. [email protected]

PMID: 12790602 DOI: 10.1021/jo026796x

Abstract

Primary and secondary cyanides are efficiently acylated with N-acylbenzotriazoles 3a-f (derived from a variety of acids) to afford the corresponding alpha-substituted beta-ketonitriles 5a-r in 67-96% yields.

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