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Waguri N, Yamamoto M. Intrahepatic cholestasis and pure red cell aplasia associated with ticlopidine. Eur J Intern Med. 2003;14(3):192-195doi: 10.1016/s0953-6205(03)00037-2.
Waguri, N., & Yamamoto, M. (2003). Intrahepatic cholestasis and pure red cell aplasia associated with ticlopidine. European journal of internal medicine, 14(3), 192-195. https://doi.org/10.1016/s0953-6205(03)00037-2
Waguri, Nobuo, and Yamamoto, Masaru. "Intrahepatic cholestasis and pure red cell aplasia associated with ticlopidine." European journal of internal medicine vol. 14,3 (2003): 192-195. doi: https://doi.org/10.1016/s0953-6205(03)00037-2
Waguri N, Yamamoto M. Intrahepatic cholestasis and pure red cell aplasia associated with ticlopidine. Eur J Intern Med. 2003 May;14(3):192-195. doi: 10.1016/s0953-6205(03)00037-2. PMID: 12798219.
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Eur J Intern Med. 2003 May;14(3):192-195. doi: 10.1016/s0953-6205(03)00037-2.

Intrahepatic cholestasis and pure red cell aplasia associated with ticlopidine.

European journal of internal medicine

Nobuo Waguri, Masaru Yamamoto

Affiliations

  1. Department of Internal Medicine, Sannocho Hospital, 2-30 Honcho 5, Sanjo City, 955-0071, Niigata, Japan

PMID: 12798219 DOI: 10.1016/s0953-6205(03)00037-2

Abstract

A 77-year-old woman developed jaundice and anemia 3 and 8 weeks, respectively, after starting ticlopidine (100 mg daily) for cerebral infarction. From the laboratory findings, including histological study of the liver and bone marrow specimen, ticlopidine-induced intrahepatic cholestasis and pure red cell aplasia were highly suspected. Jaundice slowly improved after the withdrawal of ticlopidine. Anemia immediately improved with steroid therapy. These are very rare adverse effects of ticlopidine; nevertheless, periodic laboratory examinations are recommended.

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