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Nürnberger J, Dammer S, Philipp T, et al. Metabolic and haemodynamic effects of oral glucose loading in young healthy men carrying the 825T-allele of the G protein beta3 subunit. Cardiovasc Diabetol. 2003;2:7doi: 10.1186/1475-2840-2-7.
Nürnberger, J., Dammer, S., Philipp, T., Wenzel, R. R., & Schäfers, R. F. (2003). Metabolic and haemodynamic effects of oral glucose loading in young healthy men carrying the 825T-allele of the G protein beta3 subunit. Cardiovascular diabetology, 27. https://doi.org/10.1186/1475-2840-2-7
Nürnberger, Jens, et al. "Metabolic and haemodynamic effects of oral glucose loading in young healthy men carrying the 825T-allele of the G protein beta3 subunit." Cardiovascular diabetology vol. 2 (2003): 7. doi: https://doi.org/10.1186/1475-2840-2-7
Nürnberger J, Dammer S, Philipp T, Wenzel RR, Schäfers RF. Metabolic and haemodynamic effects of oral glucose loading in young healthy men carrying the 825T-allele of the G protein beta3 subunit. Cardiovasc Diabetol. 2003 Jun 25;2:7. doi: 10.1186/1475-2840-2-7. PMID: 12890290; PMCID: PMC169176.
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Cardiovasc Diabetol. 2003 Jun 25;2:7. doi: 10.1186/1475-2840-2-7.

Metabolic and haemodynamic effects of oral glucose loading in young healthy men carrying the 825T-allele of the G protein beta3 subunit.

Cardiovascular diabetology

Jens Nürnberger, Sandra Dammer, Thomas Philipp, Rene R Wenzel, Rafael F Schäfers

Affiliations

  1. Division of Nephrology and Hypertension, University of Essen, Hufelandstrasse 55, 45122 Essen, Germany. [email protected]

PMID: 12890290 PMCID: PMC169176 DOI: 10.1186/1475-2840-2-7

Abstract

BACKGROUND: A C825T polymorphism was recently identified in the gene encoding the beta3 subunit of heterotrimeric G-proteins (GNB3). The T-allele is significantly associated with essential hypertension and obesity. In order to further explore a possible pathogenetic link between the T-allele and impaired glucose tolerance we studied metabolic and haemodynamic responses to oral glucose loading in young, healthy subjects with and without the 825T-allele.

METHODS: Twelve subjects with and 10 without the 825T-allele were investigated at rest and following glucose ingestion (75 g). Blood glucose, serum insulin and haemodynamics were determined prior to and over 2 hours following glucose ingestion. We non-invasively measured stroke volume (SV, by impedance-cardiography), blood pressure (BP), heart rate (HR), and systolic-time-intervals. Cardiac output (CO) was calculated from HR and SV. Total peripheral resistance was calculated from CO and BP. Metabolic and haemodynamic changes were quantified by maximal responses and by calculation of areas under the concentration time profile (AUC). Significances of differences between subjects with and without the T-allele were determined by unpaired two-tailed t-tests. A p < 0.05 was considered statistically significant.

RESULTS: Metabolic and haemodynamic parameters at baseline were very similar between both groups. The presence of the T-allele did not alter the response of any metabolic or haemodynamic parameter to glucose loading.

CONCLUSIONS: In conclusion, this study does not support the hypothesis that the C825T polymorphism may serve as a genetic marker of early impaired glucose tolerance.

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