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Petrik J. Fusion inhibitors. IDrugs. 2002;5(1):77-83
Petrik, J. (2002). Fusion inhibitors. IDrugs : the investigational drugs journal, 5(1), 77-83.
Petrik, J. "Fusion inhibitors." IDrugs : the investigational drugs journal vol. 5,1 (2002): 77-83.
Petrik J. Fusion inhibitors. IDrugs. 2002 Jan;5(1):77-83. PMID: 12861481.
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IDrugs. 2002 Jan;5(1):77-83.

Fusion inhibitors.

IDrugs : the investigational drugs journal

J Petrik

Affiliations

  1. Scottish National Blood Transfusion Service, LCMV Royal (Dick) Veterinary College, Summerhall, Edinburgh, EH9 1QH, UK. [email protected]

PMID: 12861481

Abstract

The majority of current antiviral drugs target viral genome replication (eg, reverse transcriptase inhibitors) or virion maturation (eg, protease inhibitors). Although efficient, these drugs suffer from the quick appearance of drug-resistant mutants and usually do not eliminate the virus completely. Combination therapy may delay but not eliminate the emerging resistant mutants. The continuing search for novel antiviral compounds has been extended to earlier stages of viral replication cycle, such as virus entry. One particular group of entry inhibitors, the fusion inhibitors, interferes with fusion of viral and host cell membranes, a post-attachment process specific for enveloped viruses.

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