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Rice ME. Ascorbate compartmentalization in the CNS. Neurotox Res. 1999;1(2):81-90doi: 10.1007/BF03033272.
Rice, M. E. (1999). Ascorbate compartmentalization in the CNS. Neurotoxicity research, 1(2), 81-90. https://doi.org/10.1007/BF03033272
Rice, M E. "Ascorbate compartmentalization in the CNS." Neurotoxicity research vol. 1,2 (1999): 81-90. doi: https://doi.org/10.1007/BF03033272
Rice ME. Ascorbate compartmentalization in the CNS. Neurotox Res. 1999 Dec;1(2):81-90. doi: 10.1007/BF03033272. PMID: 12835104.
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Neurotox Res. 1999 Dec;1(2):81-90. doi: 10.1007/BF03033272.

Ascorbate compartmentalization in the CNS.

Neurotoxicity research

M E Rice

Affiliations

  1. Department of Neurosurgery, Department of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA. [email protected]

PMID: 12835104 DOI: 10.1007/BF03033272

Abstract

Ascorbic acid, found physiologically as the ascorbate anion, is an abundant water-soluble antioxidant. It is concentrated in the intracellular compartment of all tissues in the body. The CNS has particularly high levels of ascorbate. Recent data from this laboratory indicate that ascorbate is distinctly compartmentalized between neurons and glia, with an average intracellular concentration of 10 mM in neurons and 1 mM in glial cells. These data can be contrasted with those for another important low molecular weight antioxidant, glutathione, which is somewhat more concentrated in glia than in neurons. The present review summarizes evidence for ascorbate compartmentalization between neurons and glia and considers these data in light of evidence for the roles of ascorbate as a neuroprotective antioxidant and as a neuromodulator in the CNS.

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