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Falk R. Linkage: from particulate to interactive genetics. J Hist Biol. 2003;36(1):87-117doi: 10.1023/a:1022548108762.
Falk, R. (2003). Linkage: from particulate to interactive genetics. Journal of the history of biology, 36(1), 87-117. https://doi.org/10.1023/a:1022548108762
Falk, Raphael. "Linkage: from particulate to interactive genetics." Journal of the history of biology vol. 36,1 (2003): 87-117. doi: https://doi.org/10.1023/a:1022548108762
Falk R. Linkage: from particulate to interactive genetics. J Hist Biol. 2003;36(1):87-117. doi: 10.1023/a:1022548108762. PMID: 12778899.
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J Hist Biol. 2003;36(1):87-117. doi: 10.1023/a:1022548108762.

Linkage: from particulate to interactive genetics.

Journal of the history of biology

Raphael Falk

Affiliations

  1. Department of Genetics, The Hebrew University, Jerusalem, Israel. [email protected]

PMID: 12778899 DOI: 10.1023/a:1022548108762

Abstract

Genetics was established on a strict particulate conception of heredity. Genetic linkage, the deviation from independent segregation of Mendelian factors, was conceived as a function of the material allocation of the factors to the chromosomes, rather than to the multiple effects (pleiotropy) of discrete factors. Although linkage maps were abstractions they provided strong support for the chromosomal theory of inheritance. Direct Cytogenetic evidence was scarce until X-ray induced major chromosomal rearrangements allowed direct correlation of genetic and cytological rearrangements. Only with the discovery of the polytenic giant chromosomes in Drosophila larvae in the 1930s were the virtual maps backed up by physical maps of the genetic loci. Genetic linkage became a pivotal experimental tool for the examination of the integration of genetic functions in development and in evolution. Genetic mapping has remained a hallmark of genetic analysis. The location of genes in DNA is a modern extension of the notion of genetic linkage.

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