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Breuer M, Ditrich K, Habicher T, et al. Industrial methods for the production of optically active intermediates. Angew Chem Int Ed Engl. 2004;43(7):788-824doi: 10.1002/anie.200300599.
Breuer, M., Ditrich, K., Habicher, T., Hauer, B., Kesseler, M., Stürmer, R., & Zelinski, T. (2004). Industrial methods for the production of optically active intermediates. Angewandte Chemie (International ed. in English), 43(7), 788-824. https://doi.org/10.1002/anie.200300599
Breuer, Michael, et al. "Industrial methods for the production of optically active intermediates." Angewandte Chemie (International ed. in English) vol. 43,7 (2004): 788-824. doi: https://doi.org/10.1002/anie.200300599
Breuer M, Ditrich K, Habicher T, Hauer B, Kesseler M, Stürmer R, Zelinski T. Industrial methods for the production of optically active intermediates. Angew Chem Int Ed Engl. 2004 Feb 06;43(7):788-824. doi: 10.1002/anie.200300599. PMID: 14767950.
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Angew Chem Int Ed Engl. 2004 Feb 06;43(7):788-824. doi: 10.1002/anie.200300599.

Industrial methods for the production of optically active intermediates.

Angewandte Chemie (International ed. in English)

Michael Breuer, Klaus Ditrich, Tilo Habicher, Bernhard Hauer, Maria Kesseler, Rainer Stürmer, Thomas Zelinski

Affiliations

  1. BASF Aktiengesellschaft, Forschung Feinchemikalien & Biokatalyse, 67056 Ludwigshafen, Germany.

PMID: 14767950 DOI: 10.1002/anie.200300599

Abstract

Enantiomerically pure amino acids, amino alcohols, amines, alcohols, and epoxides play an increasingly important role as intermediates in the pharmaceutical industry and agrochemistry, where both a high degree of purity and large quantities of the compounds are required. The chemical industry has primarily relied upon established chemical methods for the synthesis of these intermediates, but is now turning more and more to enzymatic and biotechnological fermentation processes. For the industrial implementation of many transformations alternative methods are available. The advantages of the individual methods will be discussed herein and exemplified by syntheses of relevant compounds.

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