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Gzil P, Vervoort N, Baron GV, et al. Advantages of perfectly ordered 2-D porous pillar arrays over packed bed columns for LC separations: a theoretical analysis. Anal Chem. 2003;75(22):6244-50doi: 10.1021/ac034345m.
Gzil, P., Vervoort, N., Baron, G. V., & Desmet, G. (2003). Advantages of perfectly ordered 2-D porous pillar arrays over packed bed columns for LC separations: a theoretical analysis. Analytical chemistry, 75(22), 6244-50. https://doi.org/10.1021/ac034345m
Gzil, P, et al. "Advantages of perfectly ordered 2-D porous pillar arrays over packed bed columns for LC separations: a theoretical analysis." Analytical chemistry vol. 75,22 (2003): 6244-50. doi: https://doi.org/10.1021/ac034345m
Gzil P, Vervoort N, Baron GV, Desmet G. Advantages of perfectly ordered 2-D porous pillar arrays over packed bed columns for LC separations: a theoretical analysis. Anal Chem. 2003 Nov 15;75(22):6244-50. doi: 10.1021/ac034345m. PMID: 14616008.
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Anal Chem. 2003 Nov 15;75(22):6244-50. doi: 10.1021/ac034345m.

Advantages of perfectly ordered 2-D porous pillar arrays over packed bed columns for LC separations: a theoretical analysis.

Analytical chemistry

P Gzil, N Vervoort, G V Baron, G Desmet

Affiliations

  1. Vrije Universiteit Brussel, Department of Chemical Engineering, Pleinlaan 2, 1050 Brussels, Belgium. [email protected]

PMID: 14616008 DOI: 10.1021/ac034345m

Abstract

A series of theoretical calculations is presented to quantify the gain in LC separation efficiency that can be expected if the traditionally used packed bed columns were replaced by columns with a perfectly ordered flow-through pore network. It is shown that a perfectly ordered 2-D array of porous cylindrical pillars could yield reduced plate heights as small as h = 0.65 (for k' ' = 0.75) to h = 0.85 (for k' ' = 2) and separation impedances as small as E = 200 (for k' ' = 0.75) to E = 300 (for k' ' = 2) without having to compromise on the porosity (epsilon = 0.4) and the retention capacity of the packed bed of spheres. Fitting the calculated van Deemter plots with Knox's equation especially shows a strong decrease of the A-term contribution, hence confirming that the improved column performance indeed stems from the increased homogeneity of the packing. The presented results, hence, provide a clear quantitative support for Knox's recent argumentation that the use of more uniform beds could greatly enhance the efficiency of pressure-driven LC.

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