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Houmam A, Hamed EM, Hapiot P, et al. Regioselective bond cleavage in the dissociative electron transfer to benzyl thiocyanates. J Am Chem Soc. 2003;125(42):12676-7doi: 10.1021/ja036710x.
Houmam, A., Hamed, E. M., Hapiot, P., Motto, J. M., & Schwan, A. L. (2003). Regioselective bond cleavage in the dissociative electron transfer to benzyl thiocyanates. Journal of the American Chemical Society, 125(42), 12676-7. https://doi.org/10.1021/ja036710x
Houmam, Abdelaziz, et al. "Regioselective bond cleavage in the dissociative electron transfer to benzyl thiocyanates." Journal of the American Chemical Society vol. 125,42 (2003): 12676-7. doi: https://doi.org/10.1021/ja036710x
Houmam A, Hamed EM, Hapiot P, Motto JM, Schwan AL. Regioselective bond cleavage in the dissociative electron transfer to benzyl thiocyanates. J Am Chem Soc. 2003 Oct 22;125(42):12676-7. doi: 10.1021/ja036710x. PMID: 14558793.
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J Am Chem Soc. 2003 Oct 22;125(42):12676-7. doi: 10.1021/ja036710x.

Regioselective bond cleavage in the dissociative electron transfer to benzyl thiocyanates.

Journal of the American Chemical Society

Abdelaziz Houmam, Emad M Hamed, Philippe Hapiot, John M Motto, Adrian L Schwan

Affiliations

  1. Department of Chemistry and Biochemistry, University of Guelph, Guelph, Ontario, Canada N1G 2W1. [email protected]

PMID: 14558793 DOI: 10.1021/ja036710x

Abstract

The electrochemical reduction of benzyl thiocyanate and p-nitrobenzyl thiocyanate was investigated in acetonitrile at an inert electrode. These two compounds reveal a change in the reductive cleavage mechanism, and more interestingly, they show a clear-cut example of a regioselective bond dissociation. Both phenomena may be understood on the basis of the dissociative ET theory and its extension to the formation/dissociation reactions of radical ions. While the effect of the standard oxidation potential of the leaving group seems to be predominant in understanding the change in the ET mechanism by changing the driving force, the regioselective cleavage is dictated by changes in the intrinsic barrier related to the nature of the substituent on the aryl moiety.

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